Published online Mar 27, 2016. doi: 10.4240/wjgs.v8.i3.212
Peer-review started: August 30, 2015
First decision: October 27, 2015
Revised: November 2, 2015
Accepted: December 13, 2015
Article in press: December 15, 2015
Published online: March 27, 2016
Core tip: Duodenal adenocarcinoma is a rare but aggressive malignancy. Complete surgical resection is recommended when technically feasible. Pancreaticoduodenectomy or segmental duodenal resection may be employed, depending on the tumor location, and either are acceptable options as long as negative margins and adequate lymphadenectomy can be achieved. Although specific data are limited, adjuvant chemotherapy and radiation should be considered for patients at high risk of recurrence.