Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Sep 27, 2026; 18(9): 122838
Published online Sep 27, 2026. doi: 10.4240/wjgs.122838
Published online Sep 27, 2026. doi: 10.4240/wjgs.122838
Coexistence of esophageal verrucous carcinoma in situ and gastric intramucosal poorly differentiated adenocarcinoma: A case report
Xing Zhang, Jun-Ying Zhou, Zhao-Wei Wu, Hong-Guang Wu, Department of Gastroenterology, The Second People’s Hospital of Quzhou, Quzhou 324022, Zhejiang Province, China
Shu-Xia Zhou, Department of Pathology, The Second People’s Hospital of Quzhou, Quzhou 324022, Zhejiang Province, China
Jin-Fu Zheng, Wang-Yong Zheng, Department of Gastrointestinal Surgery, The Second People’s Hospital of Quzhou, Quzhou City 324022, Zhejiang Province, China
Wen-Sheng Pan, Department of Gastroenterology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou 310014, Zhejiang Province, China
Co-first authors: Xing Zhang and Jun-Ying Zhou.
Co-corresponding authors: Wen-Sheng Pan and Hong-Guang Wu.
Author contributions: Zhang X, Zhou JY, Wu ZW, Zhou SX, Zheng JF, and Zheng WY wrote the article and reviewed it for important intellectual content; Pan WS and Wu HG reviewed the manuscript and supervised the writing, and they played important and indispensable roles in the manuscript preparation as the co-corresponding authors; Zhang X and Zhou JY have made crucial and indispensable contributions towards the completion of the project and thus qualify as the co-first authors of the paper.
AI contribution statement: Portions of this manuscript were edited using AI tools solely for language refinement. The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript.
Supported by Science and Technology Project of Qujiang District, Quzhou City, Zhejiang Province, No. QJ2023019; Guided Science and Technology Key Research Project of Quzhou City, No. 2023ZD091; Zhejiang Pioneer and Leading Goose Program: Research on Novel Technologies and Strategies for Precision Diagnosis and Treatment of Malignant Tumors, No. 2025C02061; and the Zhejiang Provincial Medical College Clinical Medical Research Special Fund Project, No. 2025ZYC-A162.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Hong-Guang Wu, Chief Physician, Executive Director, Department of Gastroenterology, The Second People’s Hospital of Quzhou, No. 338 Xin’an Avenue, Quzhou 324022, Zhejiang Province, China. whg665015@163.com
Received: May 6, 2026
Revised: July 1, 2026
Accepted: August 14, 2026
Published online: September 27, 2026
Processing time: 135 Days and 19.2 Hours
Revised: July 1, 2026
Accepted: August 14, 2026
Published online: September 27, 2026
Processing time: 135 Days and 19.2 Hours
Core Tip
Core Tip: This report presents an exceptionally rare case of coexisting esophageal verrucous carcinoma (EVC) in situ and gastric intramucosal poorly differentiated adenocarcinoma. It highlights the major diagnostic challenge posed by EVC, as superficial biopsies are frequently non-diagnostic and mimic benign conditions. The case underscores the critical role of endoscopic submucosal dissection (ESD), which served not only as a curative treatment but also as the definitive diagnostic procedure. By providing a full-thickness specimen, ESD ultimately confirmed the diagnosis and enabled a favorable prognosis through complete resection.