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World J Gastrointest Surg. Sep 27, 2026; 18(9): 122446
Published online Sep 27, 2026. doi: 10.4240/wjgs.122446
Published online Sep 27, 2026. doi: 10.4240/wjgs.122446
Perianal Paget’s disease with concomitant rectal cancer: A case report
Kai Lv, Long-Zhan Dong, Hui Yang, Yu-Lin Liu, Han Li, Jing-Bo Chen, Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250014, Shandong Province, China
Ke-Liang Jia, Xian-Hai Zhao, Department of Anorectal and Intestinal Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250014, Shandong Province, China
Co-first authors: Kai Lv and Long-Zhan Dong.
Author contributions: Lv K and Dong LZ contributed equally to this work and wrote the manuscript; Yang H, Liu YL and Li H collected the clinical data and prepared the figures; Jia KL and Zhao XH performed the clinical management and follow-up; Chen JB designed the study, supervised the revision and critically revised the manuscript. All authors have read and approved the final manuscript.
AI contribution statement: AI tools were used only for language refinement. No AI tool was involved in generating clinical data, interpreting results, or formulating scientific conclusions. All AI-generated outputs were reviewed and revised by the authors, who take full responsibility for the accuracy, originality and integrity of the manuscript.
Informed consent statement: Written informed consent was obtained from the patient for treatment and for publication of this case report and any accompanying anonymized clinical images.
Conflict-of-interest statement: The Authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Jing-Bo Chen, PhD, Director, Full Professor, Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, No. 16766 Jingshi Road, Jinan 250014, Shandong Province, China. qychenjingbo@163.com
Received: April 22, 2026
Revised: May 29, 2026
Accepted: July 9, 2026
Published online: September 27, 2026
Processing time: 147 Days and 7.3 Hours
Revised: May 29, 2026
Accepted: July 9, 2026
Published online: September 27, 2026
Processing time: 147 Days and 7.3 Hours
Core Tip
Core Tip: Perianal Paget’s disease is rare and may mimic benign perianal disorders, resulting in delayed diagnosis. This case highlights the need for biopsy of persistent perianal ulceration and complete anorectal evaluation. The resected specimen confirmed rectal adenocarcinoma with Paget’s disease. Immunohistochemistry showed retained mismatch repair proteins and negative BRAF expression, and molecular testing revealed no typical KRAS, NRAS, BRAF, or PIK3CA mutations.