Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Sep 27, 2026; 18(9): 122154
Published online Sep 27, 2026. doi: 10.4240/wjgs.122154
Published online Sep 27, 2026. doi: 10.4240/wjgs.122154
Clinical outcomes of endoscopic papillectomy: The experience in a Chinese tertiary hospital
Meng Zhang, Jiao Liu, Pei-Lin Zhou, Qian Zhao, Zhuo Yang, Department of Endoscopy, General Hospital of Northern Theater Command, Shenyang 110000, Liaoning Province, China
Co-first authors: Meng Zhang and Jiao Liu.
Co-corresponding authors: Qian Zhao and Zhuo Yang.
Author contributions: Zhang M, Liu J, and Yang Z significantly contributed to the conceptualization and design; Zhang M and Zhou PL conducted the literature search and data collection; Zhang M and Liu J conducted the manuscript drafting and they contributed equally to this manuscript as co-first authors; Zhao Q and Yang Z critically revised the article and they contributed equally to this manuscript as co-corresponding authors. All authors approved the final manuscript and agree to be accountable for all aspects of the work.
Supported by Liaoning Provincial Science and Technology Program, No. 2024JH2/102600288.
Institutional review board statement: The study was reviewed and approved by the General Hospital of Northern Theater Command Institutional Review Board [approval No. Y(2025)414].
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Zhuo Yang, MD, Chief Physician, Department of Endoscopy, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang 110000, Liaoning Province, China. yangzhuocy@163.com
Received: April 13, 2026
Revised: May 21, 2026
Accepted: June 22, 2026
Published online: September 27, 2026
Processing time: 157 Days and 14.7 Hours
Revised: May 21, 2026
Accepted: June 22, 2026
Published online: September 27, 2026
Processing time: 157 Days and 14.7 Hours
Core Tip
Core Tip: This single-center study presents a standardized endoscopic papillectomy protocol incorporating submucosal injection, double stenting, and clip closure, achieving high complete resection with a favorable safety profile. A key novel finding is that pre-procedural hypokalemia was identified as an independent, potentially modifiable risk factor for post-endoscopic papillectomy pancreatitis. Subgroup analyses for technical components were underpowered and hypothesis-generating only. Given the rarity of ampullary neoplasms and the difficulty of conducting prospective trials, these real-world insights offer clinically meaningful guidance while higher-level evidence is awaited.