Pei WM, Ye Y, Liu J, Tan HL, Tang YX, Liu JT. Analgesic efficacy of thoracic paravertebral block in elderly gastric cancer patients and its impact on homeostasis. World J Gastrointest Surg 2026; 18(9): 120404 [DOI: 10.4240/wjgs.120404]
Corresponding Author of This Article
Ji-Tong Liu, PhD, Department of Anesthesiology, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), No. 61 Jiefang West Road, Furong District, Changsha 410005, Hunan Province, China. liujitong999@163.com
Research Domain of This Article
Gastroenterology & Hepatology
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research-article
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Pei WM, Ye Y, Liu J, Tan HL, Tang YX, Liu JT. Analgesic efficacy of thoracic paravertebral block in elderly gastric cancer patients and its impact on homeostasis. World J Gastrointest Surg 2026; 18(9): 120404 [DOI: 10.4240/wjgs.120404]
World J Gastrointest Surg. Sep 27, 2026; 18(9): 120404 Published online Sep 27, 2026. doi: 10.4240/wjgs.120404
Analgesic efficacy of thoracic paravertebral block in elderly gastric cancer patients and its impact on homeostasis
Wan-Min Pei, Yan Ye, Jian Liu, Hui-Ling Tan, Yi-Xun Tang, Ji-Tong Liu
Wan-Min Pei, Yan Ye, Jian Liu, Hui-Ling Tan, Yi-Xun Tang, Ji-Tong Liu, Department of Anesthesiology, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha 410005, Hunan Province, China
Author contributions: Pei WM and Liu JT contributed to conceptualization; Pei WM and Tang YX contributed to methodology; Pei WM, Ye Y, and Tan HL contributed to data curation; Pei WM and Liu J contributed to formal analysis and visualization; Pei WM contributed to writing - original draft; Ye Y and Tan HL contributed to investigation and validation; Ye Y and Tang YX contributed to project administration; Liu J contributed to software and statistical analysis; Tan HL and Tang YX contributed to resources; Tang YX and Liu JT contributed to supervision; Liu JT contributed to funding acquisition, writing - review and editing, final approval of the version to be published.
AI contribution statement: AI tools were used only for grammar and language polishing. No AI was used to generate manuscript content, data, conclusions, or images. The authors take full responsibility for the entire manuscript.
Institutional review board statement: This study has been approved by the Ethics Committee of Hunan Provincial People’s Hospital (approval No.[2026]-024).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: To protect patient privacy, data will not be shared. Please contact the relevant author if necessary.
Corresponding author: Ji-Tong Liu, PhD, Department of Anesthesiology, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), No. 61 Jiefang West Road, Furong District, Changsha 410005, Hunan Province, China. liujitong999@163.com
Received: March 25, 2026 Revised: May 10, 2026 Accepted: June 16, 2026 Published online: September 27, 2026 Processing time: 173 Days and 22.3 Hours
Core Tip
Core Tip: In elderly patients undergoing laparoscopic radical gastrectomy for gastric cancer, the combination of thoracic paravertebral block and general anesthesia provides superior postoperative analgesia, as evidenced by significantly lower visual analog scale scores at 6, 24, and 48 hours. This approach also effectively mitigates the inflammatory response (lower white blood cell, neutrophil percentage, and interleukin-6), improves physiological homeostasis (lower partial pressure of CO2 and blood lactate), and reduces the incidence of postoperative nausea and vomiting and overall complications. Multiple linear regression identifies the anesthesia method as the sole independent factor for postoperative pain, while the combination shows no significant additional impact on liver and kidney function.
