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World J Gastrointest Surg. Sep 27, 2026; 18(9): 118081
Published online Sep 27, 2026. doi: 10.4240/wjgs.118081
Published online Sep 27, 2026. doi: 10.4240/wjgs.118081
Multi-omics reveal the effects of probiotics on the postoperative rehabilitation of patients with esophageal cancer
Xiao-Feng Chen, Huai-Yuan Zhang, Peng-Qiang Gao, Feng-Nian Zhuang, Wei-Jie Chen, Feng Wang, Department of Thoracic Oncology Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350001, Fujian Province, China
Co-first authors: Xiao-Feng Chen and Huai-Yuan Zhang.
Author contributions: Chen XF and Zhang HY contributed equally to this manuscript and are co-first authors. Chen XF and Wang F contributed to manuscript concept and data collection and/or processing; Chen XF, Zhang HY, and Wang F contributed to manuscript design; Zhang HY and Wang F contributed to supervision and literature search; Zhuang FN, Chen WJ, and Wang F contributed to resources; Chen XF, Zhang HY, and Chen WJ contributed to materials; Chen XF and Gao PQ contributed to analysis and/or interpretation; Chen XF and Zhang HY contributed to writing manuscript; Chen XF, Gao PQ, and Wang F contributed to critical review.
AI contribution statement: The authors declare that this manuscript did not use AI tools.
Supported by the Fujian Medical University Sailing Fund Project, No. 2020QH1235.
Institutional review board statement: The Ethics Committee of Fujian Cancer Hospital conducted the ethical review and approved this study on November 20, 2024 (No. K2024-524-01).
Informed consent statement: All the study subjects provided informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Feng Wang, Chief Physician, Department of Thoracic Oncology Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, No. 420 Fuma Road, Fuzhou 350001, Fujian Province, China. wfmd120@163.com
Received: March 17, 2026
Revised: May 6, 2026
Accepted: July 20, 2026
Published online: September 27, 2026
Processing time: 181 Days and 23.9 Hours
Revised: May 6, 2026
Accepted: July 20, 2026
Published online: September 27, 2026
Processing time: 181 Days and 23.9 Hours
Core Tip
Core Tip: In this study, analysis of the clinical outcomes of the postoperative rehabilitation of patients with esophageal squamous cell carcinoma (ESCC) receiving live combined Bifidobacterium and Lactobacillus tablets revealed the underlying mechanisms including changes in the gut microbiome and fecal metabolome. Our research offers substantial evidence regarding the role of the gut microbiota in patients with ESCC after surgery, suggesting novel avenues for targeted interventions.