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World J Gastrointest Surg. Nov 27, 2026; 18(11): 125182
Published online Nov 27, 2026. doi: 10.4240/wjgs.125182
Published online Nov 27, 2026. doi: 10.4240/wjgs.125182
Acquired hemophilia A following choledochal cyst excision - highlighting postoperative bile leak and infection as potential triggers: A case report
Shun-Rong Yuan, Li Cao, Yong Cao, Department of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing 400038, China
Xiao-Ju Li, Department of Hepatobiliary Surgery, Qujing Second People’s Hospital of Yunnan Province, Qujing 655000, Yunnan Province, China
Co-corresponding authors: Xiao-Ju Li and Yong Cao.
Author contributions: Yuan SR collected the clinical data and prepared the figures, drafted the manuscript; Cao Y and Li XJ conceived and designed the study; Cao L and Cao Y critically revised the manuscript and approved the final version; and all authors read and approved the final manuscript. Both Cao Y and Li XJ have played important and indispensable roles in the manuscript design, data interpretation and manuscript preparation as the co-corresponding authors. Li XJ applied for and obtained the funds for this research project. Cao Y conceptualized, designed, and supervised the whole process of the project. He searched the literature, revised and submitted the early version of the manuscript with the focus on the postoperative bile leak and infection as potential triggers.
AI contribution statement: No use of AI tools.
Supported by the Special Funding for the Cultivation of High-level Health Technology Professionals in Yunnan Province, No. H-2025079.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Yong Cao, MD, Department of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China. caoyong821@tmmu.edu.cn
Received: July 6, 2026
Revised: August 12, 2026
Accepted: September 20, 2026
Published online: November 27, 2026
Processing time: 134 Days and 22.5 Hours
Revised: August 12, 2026
Accepted: September 20, 2026
Published online: November 27, 2026
Processing time: 134 Days and 22.5 Hours
Core Tip
Core Tip: This report describes the first case of acquired hemophilia A after cholangiocystectomy. Postoperative bile leak with persistent abdominal infection is the key trigger for anti-factor VIII (FVIII) antibody formation. Timely FVIII testing, infection control, immunosuppression, and plasma exchange achieve cure.