Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Nov 27, 2026; 18(11): 124589
Published online Nov 27, 2026. doi: 10.4240/wjgs.124589
Published online Nov 27, 2026. doi: 10.4240/wjgs.124589
Intraoperative frozen section diagnosis of primary alpha-fetoprotein–positive hepatoid adenocarcinoma of the gallbladder: A case report
Xiao-Li Shui, Yu-Fei Liu, Institute of Pathology, China Three Gorges University, Yichang 443003, Hubei Province, China
Xiao-Li Shui, Yu-Fei Liu, Department of Pathology, Affiliated Central People’s Hospital, China Three Gorges University, Yichang 443003, Hubei Province, China
Author contributions: Shui XL and Liu YF contributed to conceptualization, data curation, investigation, visualization, and writing-original draft; Liu YF contributed to formal analysis, project administration, and writing-review and editing.
AI contribution statement: All clinical data, analyses, and conclusions were completed, reviewed, and revised by the authors. AI was not involved in data acquisition, clinical analysis, or interpretation of the results.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Yu-Fei Liu, Department of Pathology, Affiliated Central People’s Hospital, China Three Gorges University, No. 183 Yiling Boulevard, Wujiagang District, Yichang 443003, Hubei Province, China. lyf780579@163.com
Received: June 22, 2026
Revised: August 5, 2026
Accepted: September 28, 2026
Published online: November 27, 2026
Processing time: 146 Days and 19 Hours
Revised: August 5, 2026
Accepted: September 28, 2026
Published online: November 27, 2026
Processing time: 146 Days and 19 Hours
Core Tip
Core Tip: Intraoperative frozen section pathology combined with serum alpha-fetoprotein, imaging, and immunohistochemistry enables rapid and accurate diagnosis of primary alpha-fetoprotein-positive hepatoid adenocarcinoma of the gallbladder, which is crucial for guiding intraoperative surgical decisions and reducing misdiagnosis.