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Wu TT, Yang XN, Lin HH, Dong H, Yang L. Preoperative prehabilitation within enhanced recovery after surgery for postoperative frailty and functional recovery following laparoscopic colorectal cancer resection. World J Gastrointest Surg 2026; 18(11): 124456 [DOI: 10.4240/wjgs.124456]
World J Gastrointest Surg. Nov 27, 2026; 18(11): 124456 Published online Nov 27, 2026. doi: 10.4240/wjgs.124456
Preoperative prehabilitation within enhanced recovery after surgery for postoperative frailty and functional recovery following laparoscopic colorectal cancer resection
Ting-Ting Wu, Xiang-Ni Yang, Hua-Hui Lin, Hui Dong, Lin Yang
Ting-Ting Wu, Hua-Hui Lin, Hui Dong, Lin Yang, Department of Surgery, Huiqiao Medical Center, Nanfang Hospital, Guangzhou 510515, Guangdong Province, China
Xiang-Ni Yang, Tumor Radiotherapy Center, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510168, Guangdong Province, China
Author contributions: Yang L, Wu TT, Yang XN, Lin HH and Dong H contributed to the design of the research study; Wu TT, Yang XN and Lin HH contributed to the research performance and the data collection; Wu TT and Yang XN contributed to the data analysis; Yang L and Dong H contributed to the critical revisions and the supervision of the study.
AI contribution statement: The authors declare that no AI tools were used in the development or writing of this manuscript and take full responsibility for its integrity, accuracy, and originality.
Institutional review board statement: The study protocol was reviewed and approved by the Medical Ethics Committee of Nanfang Hospital, No. 2023067.
Clinical trial registration statement: This study has not yet been registered with clinical trials.
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The de-identified participant-level data supporting the findings of this study are available from the corresponding author upon reasonable request, subject to institutional and ethical approval.
Corresponding author: Lin Yang, Director, Department of Surgery, Huiqiao Medical Center, Nanfang Hospital, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou 510515, Guangdong Province, China. lisayanglin@163.com
Received: July 21, 2026 Revised: August 24, 2026 Accepted: October 10, 2026 Published online: November 27, 2026 Processing time: 113 Days and 20.6 Hours
Core Tip
Core Tip: This study focuses on patients undergoing laparoscopic colorectal cancer surgery, establishing a preoperative prehabilitation model centered on exercise and facilitated by a mobile application, with conventional enhanced recovery after surgery (ERAS) management serving as the control. The study specifically examines the impact of this model on the incidence of frailty, recovery of gastrointestinal function, physical performance, inflammatory markers, quality of life, and complications at 1 month, 3 months, and 6 months post-surgery. Through multidimensional quantitative interventions and comprehensive remote monitoring, the study aims to clarify the efficacy and mechanisms of the prehabilitation model, with the goal of optimizing ERAS perioperative management, addressing limitations in traditional interventions, and providing an evidence-based foundation for clinical rehabilitation.
