Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Nov 27, 2026; 18(11): 121769
Published online Nov 27, 2026. doi: 10.4240/wjgs.121769
Published online Nov 27, 2026. doi: 10.4240/wjgs.121769
Expression and role of the long noncoding RNA Linc00909 in chemoradiotherapy for colorectal cancer
Yong Wu, Yi-Yi Zhang, Hua-Jun Cai, Guo-Xian Guan, Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
Yong Wu, Yi-Yi Zhang, Hua-Jun Cai, Guo-Xian Guan, Department of Colorectal Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian Province, China
Bing-Jie Guan, Department of Radiation Oncology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
Bing-Jie Guan, Department of Radiation Oncology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, Fujian Province, China
Author contributions: Wu Y, Zhang YY, and Guan BJ contributed to methodology, data curation, formal analysis, and visualization; Cai HJ contributed to writing - original draft; Cai HJ and Guan GX contributed to supervision and conceptualization; and Guan GX contributed to writing - review and editing. All authors have read and approved the final version of the manuscript and agree to be accountable for all aspects of the work.
AI contribution statement: No AI tools were used in the preparation of this manuscript.
Supported by the Fujian Provincial Health Technology Project, No. 2023QNA038; Joint Funds for the Innovation of Science and Technology, Fujian Province, No. 2020Y9125; and the Fujian Province Finance Project, No. BPB-2023GGX.
Institutional review board statement: This study was approved by the Ethics Committee of the First Affiliated Hospital of Fujian Medical University (approval No. MTCA, ECFAH of FMU [2015]084-2).
Institutional animal care and use committee statement: This study was approved by the Laboratory Animal Ethics Committee of Fujian Medical University (approval No. 2023-Y-0706).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All the data generated and analyzed during this study are included in this published article.
Corresponding author: Guo-Xian Guan, MD, Professor, Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, Fujian Province, China. fjxhggx@163.com
Received: April 1, 2026
Revised: August 6, 2026
Accepted: October 16, 2026
Published online: November 27, 2026
Processing time: 225 Days and 14.6 Hours
Revised: August 6, 2026
Accepted: October 16, 2026
Published online: November 27, 2026
Processing time: 225 Days and 14.6 Hours
Core Tip
Core Tip: Linc00909 is elevated in therapy-resistant and tumor tissues of colorectal cancer and serves as an independent indicator of inferior overall and disease-free survival. Its overexpression promotes proliferation, clonogenicity, apoptosis evasion, stem-like traits, and resistance to 5-fluorouracil and radiotherapy in vitro, while accelerating tumor growth in vivo. Mechanistically, Linc00909 sponges miR-625-5p, thereby relieving repression of SOX2 and activating a Linc00909/miR-625-5p/SOX2 axis that drives therapeutic resistance. This axis is a candidate target for improving colorectal cancer treatment.