Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Surg. Oct 27, 2026; 18(10): 124385
Published online Oct 27, 2026. doi: 10.4240/wjgs.124385
Published online Oct 27, 2026. doi: 10.4240/wjgs.124385
Adjuvant chemoradiotherapy vs chemotherapy after R0 D2 gastrectomy for gastric cancer: Meta-analysis of randomized trials
Han-Hao Lu, Department of Medical Oncology, Fujian Medical University, Fuzhou 350000, Fujian Province, China
Jian-Hua Xie, Department of Radiotherapy, Mindong Hospital Affiliated to Fujian Medical University, Ningde 350000, Fujian Province, China
Xiao-Rong Li, Department of Cardiovascular Medicine, Mindong Hospital Affiliated to Fujian Medical University, Ningde 350000, Fujian Province, China
Author contributions: Lu HH conceived the study, performed the literature search and data extraction, and drafted the manuscript; Xie JH contributed to study design, data interpretation, and critical revision of the manuscript; Li XR participated in data verification, methodological assessment, and manuscript revision; all authors reviewed and approved the final version of the manuscript and agreed to be accountable for the work.
AI contribution statement: No AI tools were used in this study.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest to disclose.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Han-Hao Lu, Department of Medical Oncology, Fujian Medical University, No. 134 Dongjie Street, Gulou District, Fuzhou 350000, Fujian Province, China. 18259385886@163.com
Received: June 23, 2026
Revised: September 1, 2026
Accepted: October 10, 2026
Published online: October 27, 2026
Processing time: 116 Days and 18.6 Hours
Revised: September 1, 2026
Accepted: October 10, 2026
Published online: October 27, 2026
Processing time: 116 Days and 18.6 Hours
Core Tip
Core Tip: This synthesis links eight randomized trials after R0 D2 gastrectomy. The all-era disease-free survival estimate favored chemoradiotherapy, but treatment-backbone and provenance analyses remained imprecise. These findings do not establish equivalence or exclude meaningful benefit. The published Adjuvant Chemoradiotherapy in Stomach Tumors 2 CI is used, and source-tagged numerical inputs and reproducible sensitivity calculations are supplied.