Yang YL, Zhang TQ, Le WJ, Zhou L, Cheng H, Li YJ, Zhang KM, Yang ZC, Peng T, Lu HF. Debulking surgery for non-radically resectable intraductal papillary neoplasm of the bile duct: Three case reports and literature review. World J Gastrointest Surg 2026; 18(10): 123695 [DOI: 10.4240/wjgs.123695]
Corresponding Author of This Article
Hao-Feng Lu, MD, Associate Faculty, Chief Physician, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Yangtze University, No. 55 Jianghan North Road, Jingzhou 434000, Hubei Province, China. luhaofeng@yangtzeu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
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case-report
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Yang YL, Zhang TQ, Le WJ, Zhou L, Cheng H, Li YJ, Zhang KM, Yang ZC, Peng T, Lu HF. Debulking surgery for non-radically resectable intraductal papillary neoplasm of the bile duct: Three case reports and literature review. World J Gastrointest Surg 2026; 18(10): 123695 [DOI: 10.4240/wjgs.123695]
World J Gastrointest Surg. Oct 27, 2026; 18(10): 123695 Published online Oct 27, 2026. doi: 10.4240/wjgs.123695
Debulking surgery for non-radically resectable intraductal papillary neoplasm of the bile duct: Three case reports and literature review
Yan-Liang Yang, Tie-Quan Zhang, Wen-Jin Le, Lin Zhou, Hong Cheng, Yuan-Jun Li, Kai-Ming Zhang, Zi-Chen Yang, Tao Peng, Hao-Feng Lu
Yan-Liang Yang, Tie-Quan Zhang, Wen-Jin Le, Lin Zhou, Kai-Ming Zhang, Zi-Chen Yang, Tao Peng, Hao-Feng Lu, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei Province, China
Hong Cheng, Yuan-Jun Li, Department of Hematology, The First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei Province, China
Author contributions: Yang YL was responsible for article writing; Cheng H completed the article revision; Zhang TQ, Peng T, Le WJ, and Zhou L were responsible for figure preparation; Zhang KM, Li YJ, and Yang ZC conducted continuous follow-up of the patients; Lu HF performed the surgery and provided guidance for the writing of the paper; all authors have read and approved the final manuscript.
AI contribution statement: The authors take full responsibility and accountability for all content of this manuscript, including any portions for which AI tools were used as assistive technologies. All AI-assisted outputs were carefully reviewed, validated, and approved by the authors. AI tools were not used to generate original scientific data, perform independent scientific analyses, or draw scientific conclusions.
Supported by the Development of Science and Technology of Hubei Province, No. CXPJJH125004-013.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Hao-Feng Lu, MD, Associate Faculty, Chief Physician, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Yangtze University, No. 55 Jianghan North Road, Jingzhou 434000, Hubei Province, China. luhaofeng@yangtzeu.edu.cn
Received: May 27, 2026 Revised: July 15, 2026 Accepted: September 4, 2026 Published online: October 27, 2026 Processing time: 135 Days and 17.6 Hours
Core Tip
Core Tip: Patients with non-radically resectable intraductal papillary neoplasm of the bile (IPNB) duct usually have more severe clinical symptoms (abdominal pain, jaundice, and recurrent cholangitis), a higher risk of malignant transformation, and a worse prognosis. Therefore, proactive interventions are necessary to relieve clinical symptoms and prolong survival. Herein, we describe three patients with type I IPNB who underwent debulking surgery (left lateral segment resection, two patients; left hepatectomy, one patient). The surgery reduced tumor burden and alleviated symptoms in all patients. The findings emphasize the importance of comprehensive management of patients with IPNB for raising clinicians’ awareness and improving patient outcomes.
