Xu ZY, Ye H, Wu SH. Laparoscopic surgery for severe appendicitis in children: An effect and safety analysis. World J Gastrointest Surg 2026; 18(10): 123659 [DOI: 10.4240/wjgs.123659]
Corresponding Author of This Article
Si-Hai Wu, Surgical Intensive Care Unit, Children’s Hospital of Nanjing Medical University, No. 8 Jiangdong South Road, Jianye District, Nanjing 210000, Jiangsu Province, China. for_sea@163.com
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Surgery
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research-article
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Xu ZY, Ye H, Wu SH. Laparoscopic surgery for severe appendicitis in children: An effect and safety analysis. World J Gastrointest Surg 2026; 18(10): 123659 [DOI: 10.4240/wjgs.123659]
World J Gastrointest Surg. Oct 27, 2026; 18(10): 123659 Published online Oct 27, 2026. doi: 10.4240/wjgs.123659
Laparoscopic surgery for severe appendicitis in children: An effect and safety analysis
Zhong-Ya Xu, Hui Ye, Si-Hai Wu
Zhong-Ya Xu, Department of General Surgery, Children’s Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China
Hui Ye, Si-Hai Wu, Surgical Intensive Care Unit, Children’s Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China
Co-first authors: Zhong-Ya Xu and Hui Ye.
Author contributions: Xu ZY and Ye H designed the research and wrote the first manuscript as co-first authors; Xu ZY, Ye H and Wu SH contributed to conceiving the research, analyzing data, the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
AI contribution statement: The authors declare that no AI tools were used in the development or writing of this manuscript and take full responsibility for its integrity, accuracy, and originality.
Institutional review board statement: This study was approved by the Ethic Committee of Children’s Hospital of Nanjing Medical University, No. 202604048-1.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Data sharing statement: No additional data are available.
Corresponding author: Si-Hai Wu, Surgical Intensive Care Unit, Children’s Hospital of Nanjing Medical University, No. 8 Jiangdong South Road, Jianye District, Nanjing 210000, Jiangsu Province, China. for_sea@163.com
Received: June 2, 2026 Revised: July 2, 2026 Accepted: July 17, 2026 Published online: October 27, 2026 Processing time: 128 Days and 12.6 Hours
Core Tip
Core Tip: This study assesses the effectiveness and safety of conventional open appendectomy compared to laparoscopic appendectomy in managing severe appendicitis, including gangrenous appendicitis, perforated appendicitis, and periappendiceal abscess, in children aged 6-12 years. Laparoscopic surgery yields superior clinical benefits, as evidenced by smaller incisions, shorter surgical durations, reduced intraoperative bleeding, lower requirements for postoperative analgesics, faster gastrointestinal functional recovery, and decreased length of hospital stay, all without incurring additional hospitalization costs. Furthermore, laparoscopic surgery significantly mitigates inflammation and stress responses while actively regulating postoperative gastrointestinal hormone levels.
