Clinicopathologic features of allied disorders of Hirschsprung disease and status update

Core Tip

Core Tip: While allied disorders of Hirschsprung disease share clinical similarities with Hirschsprung’s disease (Q43.1), the pathologic manifestation and therapeutic approaches are distinct from Hirschsprung’s disease. To address the challenges in pathological diagnosis, it is necessary to develop a consensus on a reliable classification methods at the international level. First, the global standard diagnostic criteria should be established, and artificial intelligence technology can be used to perform deep learning on global data. These advances will help overcome diagnostic obstacles and enhance the accuracy of pathologic diagnosis. To define clinical guidelines, additional data collection, follow-up, and analysis are necessary to acquire improved treatment methods, prognosis, etiology, and genetic investigations.