National Cancer Database analysis of gallbladder cancer: Evaluating survival benefit of chemotherapy in early-stage gallbladder cancer

doi:10.4240/wjgs.v17.i5.103653

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May 27, 2025 (publication date) through May 23, 2025

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastrointest Surg. May 27, 2025; 17(5): 103653
Published online May 27, 2025. doi: 10.4240/wjgs.v17.i5.103653

National Cancer Database analysis of gallbladder cancer: Evaluating survival benefit of chemotherapy in early-stage gallbladder cancer

Minha Kim, Keerthivasan Vengatesan, Krist Aploks, Kyle Thompson, Xiang Dong, Ramanathan Seshadri

Minha Kim, Keerthivasan Vengatesan, Krist Aploks, Department of General Surgery, Danbury Hospital, Danbury, CT 06810, United States

Kyle Thompson, Department of Clinical Research, Danbury Hospital, Danbury, CT 06810, United States

Xiang Dong, Ramanathan Seshadri, Division of Surgical Oncology/Hepato-Pancreato-Biliary Surgery, Danbury Hospital, Danbury, CT 06810, United States

Author contributions: Kim M, Aploks K, Vengatesan K, Dong X, and Seshadri R contributed to the conceptualization of the project; Kim M, Aploks K, Thompson K, Dong X, and Seshadri R contributed to the methodology and validation of the data; Thompson K conducted the formal statistical analyses; Kim M, Vengatesan K, and Aploks K prepared the original manuscript; Kim M, Vengatesan K, Aploks K, Thompson K, Dong X, and Seshadri R contributed to the final draft revision and edition; Dong X, and Seshadri R supervised the project.

Institutional review board statement: Ethical review and approval was not required for this study since the data used was de-identified and obtained from a participant use file.

Informed consent statement: This study is a retrospective review that utilized only de-identified patient data from the National Cancer Database.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Data sharing statement: Data was obtained with the permission from the National Cancer Database. NCDB data can be obtained at https://www.facs.org/quality-programs/cancer-programs/national-cancer-database/puf/.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ramanathan Seshadri, MD, Doctor, Division of Surgical Oncology/Hepato-Pancreato-Biliary Surgery, Danbury Hospital, 95 Locus Avenue, Danbury, CT 06810, United States. ramanathan.seshadri@nuvancehealth.org

Received: November 28, 2024
Revised: March 1, 2025
Accepted: April 2, 2025
Published online: May 27, 2025
Processing time: 176 Days and 2.9 Hours

Core Tip

Core Tip: In this retrospective study, we utilized the National Cancer Database to evaluate the effect that chemotherapy has on survival of patients with stage II gallbladder cancer. While the role of chemotherapy is being investigated for stage II gallbladder cancer, surgeons should exercise caution when recommending chemotherapy to patients with early-stage gallbladder cancer as the risks may outweigh the survival benefits. Our study showed that there was no statistically significant difference in survival between the those who underwent surgery and chemotherapy compared to those who only had surgery for stage II gallbladder cancer.