Tang L, Chen LX, Luo CC, Zhao Y. Predicting risk of post-hepatectomy liver failure in patients undergoing liver resection with controlled low central venous pressure. World J Gastrointest Surg 2025; 17(5): 102335 [DOI: 10.4240/wjgs.v17.i5.102335]
Corresponding Author of This Article
Yuan Zhao, MD, Chief Physician, Department of Anesthesiology, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), No. 61 Jiefang West Road, Furong District, Changsha 410000, Hunan Province, China. zhaoyuan861@hunnu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. May 27, 2025; 17(5): 102335 Published online May 27, 2025. doi: 10.4240/wjgs.v17.i5.102335
Predicting risk of post-hepatectomy liver failure in patients undergoing liver resection with controlled low central venous pressure
Liang Tang, Ling-Xi Chen, Chu-Chu Luo, Yuan Zhao
Liang Tang, Chu-Chu Luo, Yuan Zhao, Department of Anesthesiology, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha 410000, Hunan Province, China
Ling-Xi Chen, Department of Cardiology, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha 410000, Hunan Province, China
Ling-Xi Chen, Institute of Cardiovascular Epidemiology, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha 410000, Hunan Province, China
Ling-Xi Chen, Clinical Research Center for Heart Failure in Hunan Province, Changsha 410000, Hunan Province, China
Co-first authors: Liang Tang and Ling-Xi Chen.
Author contributions: Tang L and Chen LX performed the data analyses and wrote the manuscript, and they contributed equally to this article as co-first authors; Tang L, Chen LX, Luo CC, and Zhao Y collected the data; Zhao Y and Chen LX designed the study and provided funding; and all authors approved the final manuscript.
Supported by the Natural Science Foundation of Hunan Province, No. 2018JJ3291; and the Scientific Research Project of the Hunan Provincial Health Commission, No. 202104111288.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), approval No. [2024]-273.
Informed consent statement: The informed consent was waived by the Institutional Review Board.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yuan Zhao, MD, Chief Physician, Department of Anesthesiology, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), No. 61 Jiefang West Road, Furong District, Changsha 410000, Hunan Province, China. zhaoyuan861@hunnu.edu.cn
Received: October 15, 2024 Revised: January 31, 2025 Accepted: March 13, 2025 Published online: May 27, 2025 Processing time: 219 Days and 22.6 Hours
Core Tip
Core Tip: This is the first study to establish and validate a model for predicting the risk of post-hepatectomy liver failure (PHLF) in patients undergoing hepatectomy with controlled low central venous pressure. In this work, we determined that serum albumin level, direct bilirubin level, platelet count, causes of liver resection (cancer or others), and cirrhosis were the main preoperative risk factors associated with PHLF in patients undergoing hepatectomy with controlled low central venous pressure. There is no evidence showing that intraoperative variables other than post-blocking blood potassium concentration may affect PHLF in these patients. The predictive model established in this study holds significant potential for enhancing the identification and risk stratification of patients, thereby aiding in postoperative management and improving clinical outcomes.
