Clinical and Translational Research
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Mar 27, 2024; 16(3): 842-859
Published online Mar 27, 2024. doi: 10.4240/wjgs.v16.i3.842
Construction and validation of somatic mutation-derived long non-coding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma
Bo-Tao Duan, Xue-Kai Zhao, Yang-Yang Cui, De-Zheng Liu, Lin Wang, Lei Zhou, Xing-Yuan Zhang
Bo-Tao Duan, Xue-Kai Zhao, Yang-Yang Cui, De-Zheng Liu, Lei Zhou, Xing-Yuan Zhang, Department of Hepatobiliary Surgery, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China
Lin Wang, Department of Ophthalmology, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China
Co-first authors: Bo-Tao Duan and Xue-Kai Zhao.
Author contributions: Duan BT and Zhao XK drafted the manuscript; Zhou L and Zhang XY provided guiding advice on manuscript editing. All authors approved the final version of the manuscript.
Institutional review board statement: No human or animal research was included in this study.
Clinical trial registration statement: This study is a bioinformatics article and does not involve clinical trials. There are no relevant participants involved.
Informed consent statement: No human research was included in this study.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei Zhou, MD, Full Professor, Department of Hepatobiliary Surgery, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou 256600, Shandong Province, China. dr_zhlei@163.com
Received: October 2, 2023
Peer-review started: October 2, 2023
First decision: December 8, 2023
Revised: December 20, 2023
Accepted: February 19, 2024
Article in press: February 19, 2024
Published online: March 27, 2024
Core Tip

Core Tip: Identification of genomic instability (GI)-long non-coding RNAs (LncRNAs) was conducted by combining LncRNA expression and somatic mutation profiles. The GI-LncRNAs were then analyzed for functional enrichment. The GI-derived LncRNA signature (GILncSig) was established in the training set by Cox regression analysis, and its predictive ability was verified in the testing set and TCGA set. A total of 88 GI-LncRNAs were found, and functional enrichment analysis showed that their functions were mainly involved in small molecule metabolism and GI. We established a GILncSig that can predict the prognosis of hepatocellular carcinoma patients, which will help to guide prognostic evaluation and treatment decisions.