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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2022; 14(9): 887-895
Published online Sep 27, 2022. doi: 10.4240/wjgs.v14.i9.887
Published online Sep 27, 2022. doi: 10.4240/wjgs.v14.i9.887
Research progress on the immune microenvironment of the gallbladder in patients with cholesterol gallstones
Jing-Yi Jiao, Peng Wang, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Jing-Yi Jiao, Medical School, Nantong University, Nantong 226001, Jiangsu Province, China
Xiao-Jun Zhu, Department of Hepatobiliary Surgery, Nantong First People's Hospital, Nantong 226001, Jiangsu Province, China
Chun Zhou, Department of General Practitioner, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Author contributions: Jiao JY and Zhu XJ contributed equally to this work; Wang P and Zhou C were responsible for conceiving the study; Jiao JY was responsible for writing the first draft of the article; Zhu XJ was responsible for the revision and supplement of the article.
Supported by the Wu Jiping Medical Foundation , No. 320.6750.18396 ; and Nantong “14th Five-Year” Science and Education to Strengthen Health Project , General Surgery Medical Key Discipline.
Conflict-of-interest statement: The authors declare having no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Peng Wang, MD, PhD, Chief Physician, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Nantong University, No. 20 West Temple Road, Nantong 226001, Jiangsu Province, China. dankongwang@ntu.edu.cn
Received: June 4, 2022
Peer-review started: June 4, 2022
First decision: August 1, 2022
Revised: August 19, 2022
Accepted: September 8, 2022
Article in press: September 8, 2022
Published online: September 27, 2022
Peer-review started: June 4, 2022
First decision: August 1, 2022
Revised: August 19, 2022
Accepted: September 8, 2022
Article in press: September 8, 2022
Published online: September 27, 2022
Core Tip
Core Tip: Cholesterol gallstone disease is very common. At present, some new progress has been made in the research on the pathogenesis of cholesterol gallstones, and we have also gained a new understanding of this disease. Here, we discuss the latest research progress of genetic susceptibility, intestinal microflora disorders, impaired gallbladder motility, and immune disorders in the formation of cholesterol gallstones and some new drug targets.