Published online Aug 27, 2021. doi: 10.4240/wjgs.v13.i8.822
Peer-review started: February 12, 2021
First decision: May 4, 2021
Revised: May 12, 2021
Accepted: July 5, 2021
Article in press: July 5, 2021
Published online: August 27, 2021
Core Tip: Hirschsprung’s disease (HD) is a congenital disorder, characterized by aganglionosis in the distal part of the gastrointestinal tract. Despite surgical resection of the aganglionic bowel segment, bowel dysfunction persists in a considerable number of patients with limited treatment options. There is growing evidence regarding structural abnormalities in the proximal, ganglionic colon of both humans and animals with HD, which may play a role in persistent bowel dysfunction. Hence, understanding these previously unrecognized neuropathological abnormalities in the proximal, ganglionic bowel of patients with HD may improve current follow-up and treatment of persistent postoperative bowel dysfunction in certain patients.