Observational Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Aug 27, 2020; 12(8): 355-368
Published online Aug 27, 2020. doi: 10.4240/wjgs.v12.i8.355
Drug-eluting beads transarterial chemoembolization sequentially combined with radiofrequency ablation in the treatment of untreated and recurrent hepatocellular carcinoma
Yan Zhang, Mei-Wu Zhang, Xiao-Xiang Fan, Da-Feng Mao, Quan-Hua Ding, Lu-Hui Zhuang, Shu-Yi Lv
Yan Zhang, Mei-Wu Zhang, Xiao-Xiang Fan, Da-Feng Mao, Lu-Hui Zhuang, Shu-Yi Lv, Department of Interventional Therapy, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, Zhejiang Province, China
Yan Zhang, Mei-Wu Zhang, Xiao-Xiang Fan, Da-Feng Mao, Lu-Hui Zhuang, Shu-Yi Lv, Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo 315010, Zhejiang Province, China
Yan Zhang, Mei-Wu Zhang, Xiao-Xiang Fan, Da-Feng Mao, Lu-Hui Zhuang, Shu-Yi Lv, Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo 315010, Zhejiang Province, China
Quan-Hua Ding, Department of Gastroenterology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, Zhejiang Province, China
Author contributions: Zhang MW was the guarantor and designed the study; Zhang Y, Zhang MW, Fan XX, Mao DF, and Ding QH designed the research; Zhang Y, Zhang MW, Fan XX, Mao DF, Ding QH, Zhuang LH, and Lv SY performed the research; Fan XX, Mao DF, and Ding QH contributed new analytic tools; Fan XX, Mao DF, Zhuang LH, and Lv SY analyzed data; Zhang Y, Zhang MW, Fan XX, Mao DF, and Ding QH wrote the paper and revised the article critically for important intellectual content.
Supported by Medical and Health Science and Technology Foundation of Zhejiang Province, No. 2017KY590 and No. 2019KY175; and Ningbo Clinical Research Center for Digestive System Tumors, No. 2019A21003.
Institutional review board statement: The study was approved by the ethics committee of Hwa Mei Hospital, University of Chinese Academy of Sciences.
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement, and the manuscript was prepared and revised according to the STROBE Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mei-Wu Zhang, MD, Associate Chief Physician, Department of Interventional Therapy, Hwa Mei Hospital, University of Chinese Academy of Sciences, No. 41 Xibei Street, Haishu District, Ningbo 315010, Zhejiang Province, China. zhangmeiwu@163.com
Received: April 7, 2020
Peer-review started: April 7, 2020
First decision: May 5, 2020
Revised: May 8, 2020
Accepted: July 19, 2020
Article in press: July 19, 2020
Published online: August 27, 2020
Core Tip

Core tip: Drug-eluting beads transarterial chemoembolization (DEB-TACE) can continuously and slowly release chemotherapeutic drugs compared to traditional TACE. It can maintain higher local concentrations meanwhile reducing the adverse drug reactions. DEB-TACE combined with ultrasound-guided radiofrequency ablation (RFA) has a strong anti-cancer effect, but due to its expensive price, there are fewer clinical studies. This study explored the outcome of DEA-TACE combined with RFA in the treatment of primary and recurrent hepatocellular carcinoma (HCC). The results indicated that the outcome of combined treatment for untreated HCC was comparable to hepatectomy, with less bleeding, faster recovery, and less damage to liver function. More importantly, the combination therapy has a positive effect on the treatment of recurrent HCC with fewer complications and can prolong the survival time of patients.