Zhang XJ, Fei H, Sun CY, Li ZF, Li Z, Guo CG, Zhao DB. Novel prognostic score based on the preoperative total bilirubin-albumin ratio and fibrinogen-albumin ratio in ampullary adenocarcinoma. World J Gastrointest Surg 2023; 15(10): 2247-2258 [PMID: 37969714 DOI: 10.4240/wjgs.v15.i10.2247]
Corresponding Author of This Article
Dong-Bing Zhao, MD, Doctor, Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. dbzhao@cicams.ac.cn
Research Domain of This Article
Surgery
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Xiao-Jie Zhang, He Fei, Chong-Yuan Sun, Ze-Feng Li, Zheng Li, Chun-Guang Guo, Dong-Bing Zhao, Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Zhang XJ and Fei H contributed equally to this work; Guo CG and Zhao DB designed the research study, they are the corresponding authors of this paper; Fei H and Zhang XJ analyzed the data; all authors wrote the manuscript; and all authors have read and approved the final manuscript.
Institutional review board statement: Ethical review and approval were not required for the study on human participants in accordance with the National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.
Informed consent statement: Ethical review and approval were not required for the study on human participants in accordance with the local legislation and institutional requirements.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong-Bing Zhao, MD, Doctor, Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. dbzhao@cicams.ac.cn
Received: July 3, 2023 Peer-review started: July 3, 2023 First decision: August 17, 2023 Revised: August 22, 2023 Accepted: September 4, 2023 Article in press: September 4, 2023 Published online: October 27, 2023
ARTICLE HIGHLIGHTS
Research background
Whether the relationship of preoperative total bilirubin, fibrinogen, and albumin could be used as prognostic factors is still debated.
Research motivation
The present study attempted to explore the prognostic value of total bilirubin-albumin ratio (TBAR) and fibrinogen-albumin ratio (FAR) in ampullary adenocarcinoma (AC) patients who underwent curative pancreaticoduodenectomy.
Research objectives
This study aimed to investigate whether there was an association between the novel prognostic score and poor oncologic outcomes in ampullary carcinoma.
Research methods
The clinicopathological data of ampullary carcinoma patients who underwent surgery from January 1998 to January 2020 were analyzed. Then, a novel prognostic score combining TBAR and FAR was calculated and validated through logistic regression analysis and Cox regression analysis.
Research results
Multivariable logistic regression analysis revealed that a high score was an independent protective factor for recurrence. In addition, multivariable survival analysis also demonstrated that a high score was an independent protective factor in AC patients.
Research conclusions
We found that the novel prognostic score based on the preoperative TBAR and FAR has good predictive power in AC patients who underwent curative pancreaticoduodenectomy.
Research perspectives
There are several limitations in this retrospective study, and more studies with larger samples are needed to validate this conclusion.
