Published online Sep 27, 2022. doi: 10.4240/wjgs.v14.i9.1026
Peer-review started: February 22, 2022
First decision: April 13, 2022
Revised: April 13, 2022
Accepted: August 14, 2022
Article in press: August 14, 2022
Published online: September 27, 2022
Early detection and diagnosis are crucial for the prevention and treatment of gastric cancer in clinical practice.
Blood index panels have been shown to improve the diagnostic value in many studies compared with single indices.
We aimed to develop a blood index panel that can improve the diagnostic value for discriminating gastric cancer and gastric polyps.
Tumor-related detection indices, clinical biochemical indices and cytokine indices were analyzed in samples from 139 gastric cancer patients and 40 gastric polyp patients for model building. An additional 68 gastric cancer patients and 22 gastric polyp patients were enrolled for validation.
Carbohydrate antigen (CA) 724, phosphorus (P) and ischemia-modified albumin were included in the blood index panel, and the area under the curve (AUC) index of the panel was 0.829 (0.754, 0.905). After validation, the AUC index was 0.811 (0.700, 0.923). Compared to the conventional CA724 used in the training and validation, the AUC index was 0.704 (0.617, 0.791) and 0.779 (0.668, 0.890). The blood index panel showed significantly increased diagnostic value.
We have developed a potential method for differentiating gastric cancer and gastric polyps based on a blood index panel. this tool may be helpful in clinical practice.
A healthy control group and stage of gastric cancer should be evaluated in future studies, and a larger sample size should be used.