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Zhong J, Lu YY, Xiao MY, Wu XQ. Rectal granular cell tumor treated by endoscopic resection: A case report and review of literature. World J Gastrointest Surg 2026; 18(11): 124255 [DOI: 10.4240/wjgs.124255]
Jia Zhong, Yin-Ying Lu, Ming-Ya Xiao, Xiao-Qing Wu, Department of Gastroenterology and Oncology, Changsha Hospital of Traditional Chinese Medicine, Changsha 410000, Hunan Province, China
Author contributions: Zhong J conceived the study, designed the research, analyzed the collected data, and drafted the manuscript; Zhong J and Xiao MY performed the literature search and selected relevant studies from PubMed, Web of Science, China National Knowledge Infrastructure, Wanfang Data, and VIP; Wu XQ performed the colonoscopy and provided technical guidance; Lu YY and Wu XQ supervised the study; Lu YY critically reviewed and revised the final manuscript; and all authors read and approved the final manuscript.
AI contribution statement: No AI tool was involved in the generation of research data, interpretation of results, or formulation of conclusions.
Informed consent statement: Informed written consent was obtained from the patient before operation.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Yin-Ying Lu, Associate Chief Physician, Professor, Department of Gastroenterology and Oncology, Changsha Hospital of Traditional Chinese Medicine, No. 22 Xingsha Avenue, Changsha 410000, Hunan Province, China. 1158998847@qq.com
Received: June 10, 2026 Revised: July 4, 2026 Accepted: July 27, 2026 Published online: November 27, 2026 Processing time: 155 Days and 18.2 Hours
Abstract
BACKGROUND
Granular cell tumors (GCTs) rarely occur in the gastrointestinal tract and are particularly uncommon in the rectum. We report a 34-year-old woman diagnosed with rectal GCT. In addition, we reviewed the published literature on rectal GCTs to summarize their clinical characteristics, diagnosis, and management.
CASE SUMMARY
The patient underwent a colonoscopy without any symptoms and no remarkable medical or family history of malignancy. A solitary 6-mm polypoid lesion was identified in the rectum and was resected endoscopically, with no additional lesions identified during colonoscopy. The patient had no complications after resection. Histopathological and immunohistochemical examinations confirmed the diagnosis of GCT.
CONCLUSION
The etiology, pathology, and biopsy diagnosis of GCT still require further research.
Core Tip: This article reports a middle-aged female patient with a rectal granular cell tumor (GCT) detected during colonoscopy, who had no remarkable medical or family history. The preliminary biopsy was nondiagnostic, whereas endoscopic resection followed by histopathological examination confirmed the diagnosis. We also review the literature and discuss the diagnosis, clinical and pathological features, and management of rectal GCT.
