Analysis of the clinical value of gemstone spectral computed tomography imaging in the preoperative assessment of colorectal cancer

Abstract

BACKGROUND

The diagnostic accuracy for detecting metastatic lymph nodes in colorectal cancer (CRC) remains suboptimal. To address this limitation, our study investigates the potential of gemstone spectral computed tomography imaging (GSI) to improve diagnostic accuracy in lymph node metastasis (LNM) assessment.

AIM

To extensively investigate the clinical utility of GSI in the preoperative assessment of CRC.

METHODS

The subject population included 200 patients with CRC who were admitted to Zibo Central Hospital from January 2022 to December 2023. All patients underwent dual-phase contrast-enhanced scans in the arterial and venous phases using GSI before surgical intervention. During the research, meticulous quantification was conducted regarding the number of patients with CRC with LNM as well as the exact count of metastatic lymph nodes. Moreover, for both metastatic and non-metastatic lymph nodes, the short diameter at the maximum cross-sectional area (covering the axial, sagittal, and coronal planes), morphological features (including manifestations such as margin blurring, aggregation, and enhancement), and spectral parameters in the arterial and venous phases [specifically iodine concentration (IC), normalized IC (NIC), and the slope of the spectral curve (λ_HU)] were measured and recorded, and a comparative analysis was conducted. The diagnostic efficacy of each index with differences was systematically assessed using the receiver operating characteristic (ROC) curve. Concurrently, receiver operating characteristic curves were constructed for LNM screening based on the short diameter at the maximum cross-sectional area of lymph nodes and each spectral parameter in the arterial and venous phases.

RESULTS

The area under the curve of GSI for diagnosing LNM in patients with CRC can reach 0.897, with sensitivity, specificity, and accuracy of 92.59%, 85.87%, and 89.50%, respectively. A total of 265 lymph nodes were analyzed from the 200 participants with CRC, with metastatic lymph nodes accounting for 56.60%. Compared with non-metastatic lymph nodes, the short diameters of metastatic lymph nodes in the axial, sagittal, and coronal planes were significantly increased, whereas the IC values in the arterial and venous phases, the NIC value in the arterial phase, and the λ_HU values in the arterial and venous phases were significantly decreased. The short axial, sagittal, and coronal diameters, arterial-phase IC, venous-phase IC, arterial-phase NIC, arterial-phase λ_HU, and venous-phase λ_HU for diagnosing metastatic lymph nodes demonstrated area under the curve values of 0.631, 0.681, 0.659, 0.862, 0.808, 0.831, 0.801, and 0.706, respectively.

CONCLUSION

GSI exhibits substantial clinical significance in the preoperative assessment of CRC. Among the parameters assessed, the arterial-phase IC demonstrates the most outstanding diagnostic performance, effectively improving the diagnostic efficacy for preoperative LNM in CRC.

Keywords: Gemstone spectral computed tomography imaging; Colorectal cancer; Preoperative assessment; T staging; N staging

Core Tip: To improve the diagnostic accuracy of metastatic lymph node detection in colorectal cancer (CRC), this study emphasizes the potential of gemstone spectral computed tomography imaging as a promising solution. Systematic assessment confirms that gemstone spectral computed tomography imaging demonstrates high diagnostic efficacy in detecting lymph node metastasis in patients with CRC. Among the spectral parameters analyzed across arterial and venous phases, iodine concentration in the arterial phase demonstrates the greatest diagnostic performance. These results provide novel clinical information, supporting optimized surgical decision-making and improved monitoring strategies for patients with CRC with lymph node metastasis.