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World J Gastrointest Surg. Aug 27, 2023; 15(8): 1564-1573
Published online Aug 27, 2023. doi: 10.4240/wjgs.v15.i8.1564
Prevention and treatment of hepatic encephalopathy during the perioperative period of transjugular intrahepatic portosystemic shunt
Lan-Jing Wang, Xin Yao, Qi Qi, Jian-Ping Qin
Lan-Jing Wang, Xin Yao, Qi Qi, Jian-Ping Qin, Department of Gastroenterology, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan Province, China
Author contributions: Qin JP and Yao X contributed to the conception and design of the article and revised the manuscript critically; Wang LJ and Qi Q contributed to literature search and wrote the manuscript; all authors have read and approve the final manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Data sharing statement: Not available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Ping Qin, MD, Chief Physician, Department of Gastroenterology, The General Hospital of Western Theater Command, No. 270 Rongdu Road, Chengdu 610083, Sichuan Province, China. jpqqing@163.com
Received: March 5, 2023
Peer-review started: March 5, 2023
First decision: April 21, 2023
Revised: May 9, 2023
Accepted: May 22, 2023
Article in press: May 22, 2023
Published online: August 27, 2023
Abstract

Transjugular intrahepatic portosystemic shunt (TIPS) is an established procedure for treating the complications of portal hypertension in liver cirrhosis. While the pathogenesis of postoperative TIPS-related hepatic encephalopathy (HE) has yet to be fully understood, intraoperative portosystemic shunts may provide a pathological basis for the occurrence of postoperative HE in patients with liver cirrhosis. Studies at home and abroad have expressed mixed opinions about TIPS-related HE. This study presents a literature review on the risk factors for and prevention and treatment of perioperative TIPS-related HE in patients with liver cirrhosis, aiming to optimize the procedure and reduce the incidence of postoperative HE.

Keywords: Portosystemic shunt, Transjugular intrahepatic, Hepatic encephalopathy, Liver cirrhosis, Hypertension, Portal, Therapeutics

Core tip: Transjugular intrahepatic portosystemic shunt (TIPS) is a minimally invasive interventional procedure used to treat the complications of portal hypertension in patients with liver cirrhosis of different origins. As the exact pathogenesis of postoperative TIPS-related hepatic encephalopathy (HE) remains unclear, domestic and foreign studies have expressed mixed opinions about TIPS-related HE. This study provides a literature review on the risk factors for and the prevention and treatment of perioperative TIPS-related HE.