Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Nov 27, 2022; 14(11): 1198-1203
Published online Nov 27, 2022. doi: 10.4240/wjgs.v14.i11.1198
Development and future perspectives of natural orifice specimen extraction surgery for gastric cancer
Zhi-Cao Zhang, Qi-Fa Luo, Wen-Sheng Wang, Jiang-Hong Chen, Chen-Yu Wang, Dan Ma
Zhi-Cao Zhang, Qi-Fa Luo, Wen-Sheng Wang, Jiang-Hong Chen, Chen-Yu Wang, Dan Ma, Department of General Surgery, Xinqiao Hospital of Army Medical University, Chongqing 400037, China
Author contributions: Zhang ZC and Luo QF performed the majority of the writing, and prepared the table; Luo QF, Wang WS, Chen JH, and Wang CY performed data acquisition and manuscript writing; Ma D designed the outline and coordinated the writing of the paper; and all authors have read and approved the final version to be published.
Supported by Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau), No. 2022ZDXM016.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Dan Ma, MD, Associate Chief Physician, Associate Professor, Department of General Surgery, Xinqiao Hospital of Army Medical University, No. 83 Xinqiao Main Street, Shapingba District, Chongqing 400037, China.
Received: July 18, 2022
Peer-review started: July 18, 2022
First decision: August 19, 2022
Revised: August 30, 2022
Accepted: October 18, 2022
Article in press: October 18, 2022
Published online: November 27, 2022

In recent years, natural orifice specimen extraction surgery (NOSES), a novel minimally invasive surgical technique, has become a focus in the surgical field, and has been initially applied in gastric surgery in many national medical centers worldwide. In addition, this new surgical technique was launched in major hospitals in China. With an increasing number of patients who have accepted this new surgical technique, NOSES has provided new prospects for the treatment of gastric cancer (GC), which may achieve a better outcome for both patients and surgeons. More and more experts and scholars from different countries and regions are currently paying close attention to NOSES for the treatment of GC. However, there are only a few reports of its use in GC. This review focuses on the research progress in NOSES for radical gastrectomy in recent years. We also discuss the challenges and prospects of NOSES in clinical practice.

Keywords: Gastrectomy, Gastric cancer, Laparoscopic surgery, Minimally invasive surgery, Natural orifice specimen extraction surgery, Radical gastrectomy

Core Tip: Gastric cancer (GC) is a very common malignancy worldwide. Natural orifice specimen extraction surgery (NOSES), an emerging minimally invasive surgical technique, has gradually become a new modality for the treatment of GC. NOSES has gained more and more attention as well as recognition from experts and scholars nationally and internationally. We herein discuss the research progress and application prospects of NOSES.