Association of TCF7L2 mutation and atypical diabetes in a Uruguayan population

Table 1 Anthropometric characteristics of the study population

	Healthy controls	Type 2 diabetes cases
n	133	177
Male/Female	76/57	87/90
Age (yr)	37.49 ± 13.04	63.05 ± 11.66
BMI (kg/m2)	25.17 ± 5.35	31.73 ± 5.65

BMI: Body mass index; SD: Standard deviation.

Table 2 Clinical characteristics of the atypical and classical diabetes cases

	Atypical diabetes, n = 92	Classical diabetes, n = 85	P
Age (yr)	61.29 ± 13.08	65.74 ± 9.93	0.011b
Age ( yr)	43.36 ± 12.62	45.93 ± 14.67	0.304
BMI (kg/m2)	32.22 ± 5.48	31.32 ± 5.96	0.288
HbA1c, %	8.27 ± 1.80	8.27 ± 1.77	0.993
Total cholesterol (mmol/L)	5.18 ± 1.14	5.53 ± 1.16	0.044a
HDL (mmol/L)	1.24 ± 0.29	1.32 ± 0.33	0.080
LDL (mmol/L)	2.84 ± 1.02	3.26 ± 1.11	0.010b
Triglycerides (mmol/L)	2.24 ± 1.40	2.24 ± 1.4	0.991
TG/HDL	4.47 ± 3.41	4.43 ± 4.73	0.941

^aP < 0.05,

^bP < 0.01, for all parameters. BMI: Body mass index; HbA1c: Glycated hemoglobin; HDL: High-density lipoprotein-cholesterol; LDL: Low-density lipoprotein-cholesterol; TG/HDL: Insulin resistance index.

Table 3 Genotype frequencies of rs12255372 and rs7903146 in controls and cases

SNPs	Healthy controls, %	Type 2 diabetes cases, %	OR (95%CI)	P
rs12255372 G > T
G/T + T/T	48.9	60.5	1.6 (1.02-2.51)	0.04
G/G	51.1	39.5
T allele	30	37	1.37 (0.97-1.92)	NS
G allele	70	63
rs7903146 C > T
C/T + T/T	46.6	52.5	1.27 (0.81-1.99)	NS
C/C	53.4	47.5
T allele	29	34	1.22 (0.87-1.72)	NS
C allele	71	66

CI: Confidence interval; NS: Non-significant; OR: Odds ratio; SNP: Single nucleotide polymorphism.

Table 4 Genotype frequencies of rs12255372 and rs7903146 in controls, atypical diabetes and classical diabetes patients

SNPs	Controls, %	Atypical diabetes, %	Classical diabetes, %	OR (95%CI)	P
rs12255372 G > T
G/T+T/T	65	-	57	2.1 (1.21-3.75)	0.008
G/G	68	-	28
G/T+T/T	65	50	-	1.2 (0.73-2.12)	NS
G/G	68	42	-
rs7903146 C > T
C/T + T/T	62	-	47	1.4 (0.82-2.45)	NS
C/C	71	-	38
C/T+T/T	62	46	-	1.2 (0.67-1.95)	NS
C/C	71	46	-

SNP: Single nucleotide polymorphism; CI: Confidence interval; NS: Non-significant; OR: Odds ratio; SNP: Single nucleotide polymorphism.