Hirase T, Ruff E, Surani S, Ratnani I. Topical application of platelet-rich plasma for diabetic foot ulcers: A systematic review. World J Diabetes 2018; 9(10): 172-179 [PMID: 30364787 DOI: 10.4239/wjd.v9.i10.172]
Corresponding Author of This Article
Salim Surani, FACC, FACP, MD, Adjunct Clinical Professor, Department of Medicine, Pulmonary, Critical Care and Sleep Medicine, Texas A and M University, 701 Ayers street, Corpus Christi, TX 77807, United States. srsurani@hotmail.com
Research Domain of This Article
Peripheral Vascular Disease
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
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PRP gel applied on ulcers after irrigation and debridement every week covered with non-absorbing wet dressing
PRP gel applied on ulcers after irrigation with 0.9% saline twice weekly covered with non-absorbing dressing
PRP gel applied on ulcers after irrigation twice weekly covered with foam dressings
PRP gel applied on ulcers within half an hour after preparation followed by Vaseline gauze and dressing changed every 3-4 d
PRP gel applied on ulcers covered with vapor-permeable film (Tegaderm, 3M)
PRP gel applied on ulcer with contact layer dressing covered with non-absorbent foam dressing changed every 3-4 d
PRP gel applied on ulcer after irrigation and debridement covered with Suile dressing changed every 3 d. PRP gel reapplied up to 5 times in 12 wk period if wound area reduction rate < 80%
Weekly topical application of PRP gel with covered with standard dressing changed weekly
5 mL of PRP gel applied on ulcers once a week for total of 10 wk covered with non-adherent dressing and bandage
PRP gel applied on ulces twice per week covered with occlusive dressing changed every 72 h
PRP gel applied on ulcer twice weekly after irrigation and debridement covered with standard dressings
Table 3 Platelet-rich plasma group individual study outcome measures
Table 4 Average study outcome measures included in best evidence synthesis
Time to > 90% ulcer area healing (mean ± SD, wk)
Healing rate per week (mean ± SD, cm2)
Adverse effects
PRP
7.8 ± 2.7
0.68 ± 0.56
8 (2.5)
Control
8.3 ± 3.7
0.39 ± 0.09
15 (10.5)
P-value
0.115
< 0.001
< 0.001
Citation: Hirase T, Ruff E, Surani S, Ratnani I. Topical application of platelet-rich plasma for diabetic foot ulcers: A systematic review. World J Diabetes 2018; 9(10): 172-179