Original Article
Copyright ©2012 Baishideng.
World J Diabetes. Aug 12, 2012; 3(8): 149-155
Published online Aug 12, 2012. doi: 10.4239/wjd.v3.i8.149
Table 1 Clinical and laboratory characteristics of type 1 diabetes mellitus patients
Characteristicn (%)
Age (mean ± SD, yr)12.52 ± 2.99
Age of presentation (mean ± SD, yr)8.5 ± 3.1
Gender: mean/female35 (41.2)/50 (58.8)
Weight (kg)44.55 ± 14.51
Height (cm)144.6 ± 15.55
Microalbuminuria
No80 (94.1)
Yes5 (5.9)
Frequency of DKA1.22 ± 0.91
C-peptide (fasting)0.34 ± 0.28
C-peptide (post-prandial)0.58 ± 0.64
Serum cholesterol163.95 ± 28.1
HbA1c7.98 ± 1.59
Grades of HbA1c control1
Optimal/suboptimal57 (67.1)
Poor28 (32.9)
Table 2 HLA-DQB1 allele frequency in type-1 diabetes mellitus group vs control group n (%)
HLA-DQB1 allelePatient (n = 85)Control (n = 113)OR95% CIP valuePc value
0268 (44.4)38 (18.6)3.52.19-5.65< 0.001< 0.001
020149 (32.0)36 (17.6)2.211.35-3.620.0010.014
020219 (12.4)2 (1.0)14.43.3-62.8< 0.001< 0.001
0363 (41.2)50 (24.4)2.171.38-3.41< 0.001< 0.001
0301014 (2.6)18 (8.8)0.2790.09-0.840.016NS
03020156 (36.6)6 (2.9)19.27.9-45.9< 0.001< 0.001
04017 (8.3)---
0511 (7.2)30 (14.6)0.450.22-0.930.029NS
0501016 (3.9)21 (10.2)0.350.14-0.910.025NS
0502016 (3.3)1 (0.5)6.90.79-59.60.043NS
0611 (7.2)70 (34.1)0.150.07-0.29< 0.001< 0.001
0601012 (1.3)51 (24.9)0.040.01-0.17< 0.001< 0.001
06034 (2.6)-2.372.1-2.70.020NS
0604014 (2.6)1 (0.5)5.480.6-49.50.090NS
Table 3 HLA-DQB1 genotype1 frequency in type 1 diabetes mellitus group vs control n (%)
HLA-DQB1 genotypePatient (n = 85)Control (n = 113)OR95% CIP valuePc value
02/0214 (16.5)3 (2.7)7.232.01-26.10.0010.01
02/0338 (44.7)8 (7.1)10.614.56-24.5< 0.001< 0.001
02/04-7 (6.3)1.011.02-1.180.01NS
02/056 (7.1)4 (3.5)2.070.56-7.570.26NS
02/066 (7.1)16 (14.2)0.460.17-1.230.16NS
03/0312 (14.1)6 (5.3)2.931.05-8.160.033NS
03/054 (4.7)8 (7.1)0.650.19-2.230.48NS
03/062 (2.4)22 (19.5)0.10.02-0.44< 0.00< 0.001
05/061 (1.2)11 (9.7)0.110.01-0.870.012NS
06/062 (2.4)16 (14.2)0.150.03-0.650.0040.04
Table 4 HLA-DQB1 genotype1 frequency in relation to grades of diabetic control n (%)
HLA-DQB1 genotypeOptimal control (n = 57)Poor control (n = 28)OR (95% CI)P value
02/0210 (65.9)4 (60.5)1.277 (0.36-4.49)0.703
02/0326 (34.1)12 (39.5)1.19 (0.45-2.78)0.810
02/054 (39.4)2 (28.9)0.981 (0.18-5.71)0.983
02/065 (53.0)1 (63.2)2.59 (0.29-23.35)0.379
03/037 (7.6)5 (7.9)0.644 (0.19-2.25)0.488
03/05311.5 (0.15-15.11)0.729
06/06110.482 (0.03-8.01)0.603