Nutritional programming of pancreatic β-cell plasticity

Table 1 Changes in relative gene expression assessed by DNA microarray for monolayer cells cultures

Gene	De-differentiate control diet	Re-differentiate control diet	Re-differentiateLP diet
Ins 1	-46.1	-0.1	-20.5
Somatostatin	-61.2	+2.0	-5.6
Pdx1	-1.7	-0.4	-2.3
Pax6	-23.0	-0.4	-15.7
Ngn3	-2.5	-0.5	-1.5

Values represent fold differences in mRNA expression relative to freshly isolated neonatal mouse islets (n = 3). Cell cultures were derived from the de-differentiation of neonatal mouse islets and subsequently re-differentiated to yield pseudo-islets. Donor animals were exposed to either control or low protein (LP) diet during gestation.