Stem cell therapy for diabetes: Advances, prospects, and challenges

doi:10.4239/wjd.v16.i7.107344

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Jul 15, 2025 (publication date) through Jul 18, 2025

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World Journal of Diabetes

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World J Diabetes. Jul 15, 2025; 16(7): 107344
Published online Jul 15, 2025. doi: 10.4239/wjd.v16.i7.107344

Table 1 Clinical trials of mesenchymal stem cell-based stem cell therapies for diabetes

MSCs source	Clinical trials
MSCs source	Diabetes	Type 1 diabetes	Type 2 diabetes	Diabetic foot	Diabetic nephropathy	Others
Umbilical cord-derived MSCs	NCT04972890NCT05631444NCT06751199NCT02579148	NCT01143168NCT01219465NCT01374854NCT03484741NCT05003908NCT06407297	NCT01142050NCT01413035NCT01954147NCT02302599NCT02886884NCT02945449NCT03751735NCT04441658NCT04501341NCT05507697NCT06727721	NCT02672280NCT06373809NCT01216865NCT02834858NCT04104451NCT04464213NCT06231771NCT06812637	NCT03288571NCT04125329NCT04562025NCT04216849	NCT02745808NCT02763423
Bone marrow-derived MSCs	NCT02387749	NCT01157403NCT03361631NCT02893306NCT04078308	NCT00644241NCT01694173NCT01719640NCT01759823NCT03343782NCT03943940	NCT01686139NCT00955669NCT02796079NCT03248466NCT05783115
Adipose-derived MSCs	NCT01257776	NCT02940418NCT03920397NCT05308836	NCT06605508	NCT03259217NCT05610865NCT03865394NCT03916211NCT04466007NCT05595681	NCT04869761NCT03840343
MSCs from other sources	NCT02384018	NCT01496339		NCT06003530
Unknown origin MSCs	NCT04776239	NCT00646724NCT01068951NCT02057211NCT04061746NCT01322789	NCT01786707NCT02286128	NCT02304588

MSC: Mesenchymal stem cell.

Citation: Zuo DB, Wang CH, Sang M, Sun XD, Chen GP, Ji KK. Stem cell therapy for diabetes: Advances, prospects, and challenges. World J Diabetes 2025; 16(7): 107344
URL: https://www.wjgnet.com/1948-9358/full/v16/i7/107344.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i7.107344