Examining gut microbiota and metabolites to clarify mechanisms of Dimocarpus longan Lour leaf components against type 2 diabetes

doi:10.4239/wjd.v16.i7.104512

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 7

This Article

(90)

(77)

(0)

(2159)

(3)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Diabetes

ISSN

1948-9358

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Diabetes. Jul 15, 2025; 16(7): 104512
Published online Jul 15, 2025. doi: 10.4239/wjd.v16.i7.104512

Table 1 Differential metabolites

No.	Metabolites	t_R/minute	m/z	Formula	Mode	HMDB ID	Trend
No.	Metabolites	t_R/minute	m/z	Formula	Mode	HMDB ID	Con/Mod	Mod/DLC
1	Eriodictyol	5.652	269.04530	C₁₅H₁₂O₆	ESI-	HMDB0005810	↓	↑
2	N-Acetyl-D-galactosamine 4-sulfate	1.307	300.03916	C₈H₁₅NO₉S	ESI-	HMDB0000781	↑	↑
3	α-ketoglutaric acid	1.481	145.01309	C₅H₆O₅	ESI-	HMDB0000208	↑	↓
4	Palmitic acid	10.254	255.23257	C₁₆H₃₂O₂	ESI-	HMDB0000220	↓	↑
5	2,3-Dihydroxybenzoic acid	4.998	153.01833	C₇H₆O₄	ESI-	HMDB0000397	↓	↑
6	L-Ascorbic acid 2-sulfate	1.512	254.98142	C₆H₈O₉S	ESI-	HMDB0060649	↓	↑
7	2-Methylglutaric acid	5.244	145.04955	C₆H₁₀O₄	ESI-	HMDB0000422	↑	↓
8	Ascorbic acid	2.571	175.02375	C₆H₈O₆	ESI-	HMDB0000044	↓	↑
9	4-Methylvaleric Acid	5.819	231.15956	C₆H₁₂O₂	ESI-	HMDB0000689	↑	↓
10	Taurolithocholic acid 3-sulfate	5.789	562.24355	C₂₆H₄₅NO₈S₂	ESI-	HMDB0002580	↓	↑
11	Caffeic acid	5.337	179.03762	C₉H₈O₄	ESI-	HMDB0001964	↓	↑
12	Citramalic acid	4.201	147.03161	C₅H₈O₅	ESI-	HMDB0000426	↓	↑
13	7-Ketolithocholic acid	6.960	389.26952	C₂₄H₃₈O₄	ESI-	HMDB0000467	↑	↓
14	Anacardic acid	8.440	347.25888	C₂₂H₃₆O₃	ESI-	HMDB0033896	↑	↓
15	Phenylpyruvic acid	5.521	163.03907	C₉H₈O₃	ESI-	HMDB0000205	↑	↓
16	Gamma-Caprolactone	5.150	273.13431	C₆H₁₀O₂	ESI-	HMDB0003843	↑	↓
17	Syringic acid	3.826	197.04482	C₉H₁₀O₅	ESI-	HMDB0002085	↓	↑
18	Asp-Phe	5.159	279.09876	C₁₃H₁₆N₂O₅	ESI-	HMDB0000706	↑	↓
19	Palmitoylcarnitine	8.360	398.32717	C₂₃H₄₅NO₄	ESI-	HMDB0240774	↓	↑
20	L-Kynurenine	3.964	207.07683	C₁₀H₁₂N₂O₃	ESI-	HMDB0000684	↑	↓
21	2,3,4-Trihydroxybenzoic acid	4.767	169.01344	C₇H₆O₅	ESI-	HMDB0059964	↓	↑
22	7-Methylxanthine	2.950	165.04090	C₆H₆N₄O₂	ESI-	HMDB0001991	↑	↓
23	N-Acetyl-L-histidine	1.349	196.07196	C₈H₁₁N₃O₃	ESI-	HMDB0032055	↑	↓
24	D-Glucosamine 6-phosphate	1.287	258.03813	C₆H₁₄NO₈P	ESI-	HMDB0001254	↓	↑
25	Allantoin	1.297	157.03556	C₄H₆N₄O₃	ESI-	HMDB0000462	↓	↑
26	LPC 20: 3	8.96	590.34664	C₂₈H₅₂NO₇P	ESI-	-	↓	↑
27	ADP-ribose	1.390	560.07848	C₁₅H₂₁N₅O₁₃P₂	ESI-	HMDB0249529	↓	↑
28	Creatine	1.321	132.07689	C₄H₉N₃O₂	ESI+	HMDB0000064	↓	↑
29	N6,N6,N6-Trimethyl-L-lysine	1.180	189.16000	C₉H₂₀N₂O₂	ESI+	HMDB0001325	↓	↑
30	Propionylcarnitine	3.040	218.13907	C₁₀H₁₉NO₄	ESI+	HMDB0000824	↓	↑
31	Biotin	5.387	245.09590	C₁₀H₁₆N₂O₃S	ESI+	HMDB0000030	↑	↓
32	Argininosuccinic acid	1.283	291.12971	C₁₀H₁₈N₄O₆	ESI+	HMDB0000052	↓	↑
33	Glycitein	5.804	285.07588	C₁₆H₁₂O₅	ESI+	HMDB0005781	↓	↑
34	L-Saccharopine	1.248	277.13934	C₁₁H₂₀N₂O₆	ESI+	HMDB0000279	↓	↑
35	Histidine	1.376	139.05028	C₆H₉N₃O₂	ESI+	HMDB0000177	↑	↓
36	3-(3,4-dihydroxyphenyl) propanoic acid	5.224	165.05499	C₉H₁₀O₄	ESI+	HMDB0000423	↓	↑
37	Glu-Thr	1.371	114.06653	C₉H₁₆N₂O₆	ESI+	HMDB0028829	↓	↑
38	N-(5-Aminopentyl) acetamide	1.743	145.13362	C₇H₁₆N₂O	ESI+	HMDB0002284	↓	↑
39	Mycophenolic acid	1.242	321.12973	C₁₇H₂₀O₆	ESI+	HMDB0015159	↓	↑
40	3-Methoxytyramine	5.595	150.09125	C₉H₁₃NO₂	ESI+	HMDB0000022	↑	↓
41	Ornithine	1.140	116.07090	C₅H₁₂N₂O₂	ESI+	HMDB0000214	↑	↓
42	Muscone	9.526	239.23704	C₁₆H₃₀O	ESI+	HMDB0034181	↓	↑
43	Ethyl oleate	9.587	311.29466	C₂₀H₃₈O₂	ESI+	HMDB0034451	↓	↑
44	4-Guanidinobutanoic acid	5.254	146.09272	C₅H₁₁N₃O₂	ESI+	HMDB0003464	↑	↓
45	Arachidonic acid methyl ester	6.421	319.26285	C₂₁H₃₄O₂	ESI+	HMDB0062594	↑	↓
46	Citrulline	1.890	176.10324	C₆H₁₃N₃O₃	ESI+	HMDB0250742	↑	↓
47	Xanthurenic acid	5.081	206.04522	C₁₀H₇NO₄	ESI+	HMDB0000881	↑	↓
48	D-Alanyl-D-alanine	5.737	161.09236	C₆H₁₂N₂O₃	ESI+	HMDB0003459	↓	↑
49	Leu-Pro	3.991	211.14435	C₁₁H₂₀N₂O₃	ESI+	HMDB0011175	↓	↑
50	gamma-Glutamyltyrosine	4.943	311.12415	C₁₄H₁₈N₂O₆	ESI+	HMDB0011741	↑	↓
51	Xanthine	2.026	153.04077	C₅H₄N₄O₂	ESI+	HMDB0000292	↑	↓
52	dAMP	1.990	332.07433	C₁₀H₁₄N₅O₆P	ESI+	HMDB0000905	↓	↑
53	Uracil	1.681	113.03489	C₄H₄N₂O₂	ESI+	HMDB0000300	↑	↓
54	Urocanic acid	1.378	139.05026	C₆H₆N₂O₂	ESI+	HMDB0000301	↑	↓
55	22(S)-Hydroxycholesterol	9.474	403.3570	C₂₇H₄₆O₂	ESI+	-	↓	↑
56	PC O-20:3	8.945	546.35561	C₂₈H₅₂NO₇P	ESI+	-	↓	↑
57	PC O-18:1	9.181	522.35554	C₂₆H₅₂NO₇P	ESI+	-	↓	↑

DLC: Dimocarpus longan Lour leaf components; Con: Control group; Mod: The model group.

Full Size Table

Citation: Zheng PX, Lu CL, Liang YL, Ma YM, Peng JW, Xie JJ, Wei JL, Chen SS, Ma ZD, Zhu H, Liang J. Examining gut microbiota and metabolites to clarify mechanisms of Dimocarpus longan Lour leaf components against type 2 diabetes. World J Diabetes 2025; 16(7): 104512
URL: https://www.wjgnet.com/1948-9358/full/v16/i7/104512.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i7.104512

Zheng PX, Lu CL, Liang YL, Ma YM, Peng JW, Xie JJ, Wei JL, Chen SS, Ma ZD, Zhu H, Liang J. Examining gut microbiota and metabolites to clarify mechanisms of Dimocarpus longan Lour leaf components against type 2 diabetes. World J Diabetes 2025; 16(7): 104512 [PMID: 40697601 DOI: 10.4239/wjd.v16.i7.104512]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.