Prospective Study
Copyright ©The Author(s) 2024.
World J Diabetes. Apr 15, 2024; 15(4): 697-711
Published online Apr 15, 2024. doi: 10.4239/wjd.v15.i4.697
Table 1 Baseline characteristics of participants by diabetes and controls for analysis of ocular conditions
< 45 yr1
45-49 yr1
50-54 yr1
55-59 yr1
60-64 yr1
≥ 65 yr1
Non-diabetesDiabetesNon-diabetesDiabetesNon-diabetesDiabetesNon-diabetesDiabetesNon-diabetesDiabetesNon-diabetesDiabetes
Age (yr)51.9 ± 8.451.9 ± 7.954.7 ± 8.654.7 ± 5.858.7 ± 7.858.7 ± 4.862.2 ± 5.962.0 ± 3.565.0 ± 3.664.9 ± 2.467.6 ± 2.767.6 ± 1.4
Gender
Female1032 (36.8)506 (36.1)743 (33.4)400 (36.0)1163 (37.0)600 (38.2)1312 (36.0)652 (35.8)1075 (35.8)541 (36.0)402 (39.5)202 (39.7)
Male1774 (63.2)897 (63.9)1481 (66.6)712 (64.0)1979 (63.0)971 (61.8)2330 (64.0)1169 (64.2)1927 (64.2)960 (64.0)616 (60.5)307 (60.3)
Ethnicity
Whites1937 (69.0)968 (69.0)1634 (73.5)812 (73.0)2522 (80.3)1255 (79.9)3225 (88.6)1600 (87.9)2715 (90.4)1352 (90.1)939 (92.2)469 (92.1)
Non-whites785 (28.0)421 (30.0)535 (24.1)296 (26.6)548 (17.4)297 (18.9)367 (10.1)207 (11.4)245 (8.2)141 (9.4)71 (7.0)36 (7.1)
Unknown84 (3.0)14 (1.0)55 (2.5)4 (0.4)72 (2.3)19 (1.2)50 (1.4)14 (0.8)42 (1.4)8 (0.5)8 (0.8)4 (0.8)
Education
0-5 yr863 (30.8)379 (27.0)640 (28.8)266 (23.9)839 (26.7)397 (25.3)907 (24.9)436 (23.9)650 (21.7)318 (21.2)206 (20.2)105 (20.6)
6-12 yr1270 (45.3)687 (49.0)1108 (49.8)597 (53.7)1524 (48.5)776 (49.4)1631 (44.8)853 (46.8)1368 (45.6)681 (45.4)419 (41.2)202 (39.7)
≥ 13 yr567 (20.2)292 (20.8)421 (18.9)225 (20.2)706 (22.5)361 (23.0)1044 (28.7)493 (27.1)927 (30.9)477 (31.8)369 (36.2)192 (37.7)
Missing106 (3.8)45 (3.2)55 (2.5)24 (2.2)73 (2.3)37 (2.4)60 (1.6)39 (2.1)57 (1.9)25 (1.7)24 (2.4)10 (2.0)
Household income (pounds)
< 18000680 (24.2)418 (29.8)575 (25.9)320 (28.8)846 (26.9)470 (29.9)1075 (29.5)550 (30.2)912 (30.4)528 (35.2)372 (36.5)209 (41.1)
18000-30999529 (18.9)285 (20.3)446 (20.1)242 (21.8)696 (22.2)328 (20.9)868 (23.8)445 (24.4)751 (25.0)371 (24.7)267 (26.2)121 (23.8)
31000-51999535 (19.1)244 (17.4)420 (18.9)211 (19.0)576 (18.3)273 (17.4)600 (16.5)297 (16.3)454 (15.1)218 (14.5)110 (10.8)55 (10.8)
52000-100000369 (13.2)152 (10.8)319 (14.3)129 (11.6)356 (11.3)184 (11.7)353 (9.7)171 (9.4)227 (7.6)102 (6.8)52 (5.1)22 (4.3)
> 100000101 (3.6)44 (3.1)67 (3.0)25 (2.2)80 (2.5)34 (2.2)99 (2.7)42 (2.3)55 (1.8)17 (1.1)14 (1.4)5 (1.0)
Unknown212 (7.6)103 (7.3)128 (5.8)77 (6.9)169 (5.4)121 (7.7)182 (5.0)96 (5.3)178 (5.9)92 (6.1)57 (5.6)32 (6.3)
Not answered380 (13.5)157 (11.2)269 (12.1)108 (9.7)419 (13.3)161 (10.2)465 (12.8)220 (12.1)425 (14.2)173 (11.5)146 (14.3)65 (12.8)
Physical activity (MET-minutes/week)2287 ± 21622264 ± 22012281 ± 21532223 ± 21762205 ± 19592197 ± 21422350 ± 22042366 ± 22312475 ± 22302376 ± 21882553 ± 21132523 ± 2360
Alcohol consumption
Never365 (13.0)209 (14.9)250 (11.2)142 (12.8)296 (9.4)148 (9.4)272 (7.5)121 (6.6)191 (6.4)92 (6.1)73 (7.2)33 (6.5)
Previous196 (7.0)125 (8.9)141 (6.3)96 (8.6)201 (6.4)129 (8.2)216 (5.9)130 (7.1)141 (4.7)116 (7.7)61 (6.0)33 (6.5)
Current2192 (78.1)1063 (75.8)1804 (81.1)868 (78.1)2623 (83.5)1288 (82.0)3144 (86.3)1563 (85.8)2662 (88.7)1292 (86.1)881 (86.5)442 (86.8)
Missing53 (1.9)6 (0.4)29 (1.3)6 (0.5)22 (0.7)6 (0.4)10 (0.3)7 (0.4)8 (0.3)1 (0.1)3 (0.3)1 (0.2)
Smoking
Never1549 (55.2)831 (59.2)1082 (48.7)554 (49.8)1524 (48.5)741 (47.2)1605 (44.1)779 (42.8)1261 (42.0)627 (41.8)406 (39.9)191 (37.5)
Former846 (30.1)366 (26.1)783 (35.2)380 (34.2)1245 (39.6)639 (40.7)1621 (44.5)840 (46.1)1472 (49.0)728 (48.5)511 (50.2)274 (53.8)
Current368 (13.1)193 (13.8)341 (15.3)173 (15.6)355 (11.3)176 (11.2)400 (11.0)188 (10.3)251 (8.4)133 (8.9)99 (9.7)41 (8.1)
Missing43 (1.5)13 (0.9)18 (0.8)5 (0.4)18 (0.6)15 (1.0)16 (0.4)14 (0.8)18 (0.6)13 (0.9)2 (0.2)3 (0.6)
Sleep duration (h)
< 7871 (31.0)462 (32.9)685 (30.8)391 (35.2)907 (28.9)475 (30.2)957 (26.3)517 (28.4)705 (23.5)359 (23.9)249 (24.5)124 (24.4)
7-91768 (63.0)845 (60.2)1436 (64.6)653 (58.7)2076 (66.1)1002 (63.8)2533 (69.5)1205 (66.2)2151 (71.7)1071 (71.4)727 (71.4)358 (70.3)
> 9107 (3.8)72 (5.1)57 (2.6)52 (4.7)106 (3.4)70 (4.5)116 (3.2)80 (4.4)112 (3.7)56 (3.7)31 (3.0)18 (3.5)
Missing60 (2.1)24 (1.7)46 (2.1)16 (1.4)53 (1.7)24 (1.5)36 (1.0)19 (1.0)34 (1.1)15 (1.0)11 (1.1)9 (1.8)
BMI (kg/m2)31.4 ± 6.831.5 ± 6.531.7 ± 6.631.9 ± 6.231.6 ± 6.431.8 ± 5.931.1 ± 5.731.2 ± 5.430.6 ± 5.430.8 ± 5.230.0 ± 4.830.2 ± 4.8
Cholesterol (mmol/L)4.70 ± 1.024.63 ± 1.104.64 ± 0.984.60 ± 1.094.63 ± 0.964.57 ± 1.074.59 ± 0.974.52 ± 1.034.65 ± 0.964.60 ± 1.044.76 ± 1.014.66 ± 1.05
HDL-C (mmol/L)1.22 ± 0.321.21 ± 0.321.21 ± 0.301.21 ± 0.321.23 ± 0.311.23 ± 0.301.23 ± 0.311.22 ± 0.301.25 ± 0.311.25 ± 0.301.28 ± 0.311.26 ± 0.31
LDL-C (mmol/L)2.85 ± 0.732.83 ± 0.822.80 ± 0.712.79 ± 0.802.77 ± 0.702.76 ± 0.782.73 ± 0.692.72 ± 0.752.78 ± 0.702.77 ± 0.782.86 ± 0.732.80 ± 0.77
Triglycerides (mmol/L)2.03 ± 1.432.02 ± 1.222.12 ± 1.472.10 ± 1.242.12 ± 1.432.09 ± 1.202.15 ± 1.382.16 ± 1.232.06 ± 1.272.08 ± 1.062.04 ± 1.202.07 ± 1.09
HbA1c (mmol/mol)36.3 ± 5.454.3 ± 17.2236.7 ± 5.852.6 ± 15.5236.9 ± 5.551.4 ± 14.2237.3 ± 5.349.7 ± 12.4237.3 ± 6.747.6 ± 10.8237.5 ± 4.546.5 ± 10.42
Hypertension1501 (53.5)764 (54.5)1307 (58.8)671 (60.3)2079 (66.2)1012 (64.4)2414 (66.3)1179 (64.7)1963 (65.4)984 (65.6)643 (63.2)340 (66.8)
Heart disease301 (10.7)147 (10.5)306 (13.8)154 (13.8)450 (14.3)221 (14.1)607 (16.7)293 (16.1)556 (18.5)271 (18.1)183 (18.0)90 (17.7)
Depression300 (10.7)142 (10.1)167 (7.5)99 (8.9)230 (7.3)109 (6.9)284 (7.8)142 (7.8)160 (5.3)82 (5.5)42 (4.1)22 (4.3)
Table 2 Baseline characteristics of participants by diabetes and controls for analysis of vision acuity1
< 45 yr
45-49 yr
50-54 yr
55-59 yr
60-64 yr
≥ 65 yr
Non-diabetes
Diabetes
Non-diabetes
Diabetes
Non-diabetes
Diabetes
Non-diabetes
Diabetes
Non-diabetes
Diabetes
Non-diabetes
Diabetes
Age (yr)53.1 ± 8.652.8 ± 8.554.8 ± 8.554.7 ± 5.859.0 ± 7.958.9 ± 4.862.5 ± 5.962.3 ± 3.565.2 ± 3.665.0 ± 2.467.5 ± 2.867.6 ± 1.3
Gender
Female751 (37.6)379 (37.9)577 (36.4)284 (35.8)937 (39.2)480 (40.2)1035 (35.5)512 (35.1)962 (36.7)485 (37.1)363 (41.4)177 (40.4)
Male1249 (62.5)621 (62.1)1009 (63.6)509 (64.2)1453 (60.8)715 (59.8)1879 (64.5)945 (64.9)1656 (63.3)824 (62.9)513 (58.6)261 (59.6)
Ethnicity
Whites1268 (63.4)606 (60.6)1078 (68.0)518 (65.3)1793 (75.0)866 (72.5)2478 (85.0)1223 (83.9)2302 (87.9)1122 (85.7)768 (87.7)379 (86.5)
Non-whites611 (30.6)373 (37.3)454 (28.6)270 (34.0)511 (21.4)306 (25.6)378 (13.0)222 (15.2)267 (10.2)172 (13.1)86 (9.8)54 (12.3)
Unknown121 (6.1)21 (2.1)54 (3.4)5 (0.6)86 (3.6)23 (1.9)58 (2.0)12 (0.8)49 (1.9)15 (1.1)22 (2.5)5 (1.1)
Education
0-5 yr585 (29.3)285 (28.5)490 (30.9)215 (27.1)683 (28.6)330 (27.6)755 (25.9)359 (24.6)619 (23.6)306 (23.4)193 (22.0)92 (21.0)
6-12 yr942 (47.1)487 (48.7)811 (51.1)430 (54.2)1171 (49.0)589 (49.3)1359 (46.6)693 (47.6)1156 (44.2)590 (45.1)375 (42.8)183 (41.8)
≥ 13 yr369 (18.5)192 (19.2)239 (15.1)130 (16.4)462 (19.3)244 (20.4)736 (25.3)370 (25.4)783 (29.9)385 (29.4)287 (32.8)151 (34.5)
Missing104 (5.2)36 (3.6)46 (2.9)18 (2.3)74 (3.1)32 (2.7)64 (2.2)35 (2.4)60 (2.3)28 (2.1)21 (2.4)12 (2.7)
Household income (pounds)
< 18000475 (23.8)266 (26.6)359 (22.6)217 (27.4)607 (25.4)330 (27.6)842 (28.9)418 (28.7)796 (30.4)414 (31.6)286 (32.6)165 (37.7)
18000-30999377 (18.9)212 (21.2)346 (21.8)167 (21.1)521 (21.8)244 (20.4)718 (24.6)370 (25.4)673 (25.7)341 (26.1)227 (25.9)106 (24.2)
31000-51999372 (18.6)179 (17.9)313 (19.7)143 (18.0)415 (17.4)205 (17.2)493 (16.9)245 (16.8)402 (15.4)199 (15.2)120 (13.7)55 (12.6)
52000-100000256 (12.8)113 (11.3)234 (14.8)106 (13.4)298 (12.5)151 (12.6)301 (10.3)149 (10.2)220 (8.4)106 (8.1)52 (5.9)23 (5.3)
> 10000072 (3.6)34 (3.4)61 (3.8)24 (3.0)77 (3.2)29 (2.4)82 (2.8)36 (2.5)54 (2.1)15 (1.1)14 (1.6)5 (1.1)
Unknown132 (6.6)76 (7.6)70 (4.4)56 (7.1)122 (5.1)83 (6.9)117 (4.0)71 (4.9)126 (4.8)71 (5.4)44 (5.0)24 (5.5)
Not answered316 (15.8)120 (12.0)203 (12.8)80 (10.1)350 (14.6)153 (12.8)361 (12.4)168 (11.5)347 (13.3)163 (12.5)133 (15.2)60 (13.7)
Physical activity (MET-minutes/week)2225 ± 20872269 ± 21342154 ± 20192147 ± 20862206 ± 20232180 ± 21712433 ± 21902384 ± 22042410 ± 22062426 ± 22312591 ± 23412518 ± 2271
Alcohol consumption
Never233 (11.7)156 (15.6)178 (11.2)106 (13.4)205 (8.6)135 (11.3)213 (7.3)107 (7.3)168 (6.4)91 (7.0)60 (6.8)30 (6.8)
Previous110 (5.5)78 (7.8)96 (6.1)58 (7.3)138 (5.8)85 (7.1)170 (5.8)81 (5.6)131 (5.0)77 (5.9)55 (6.3)34 (7.8)
Current1595 (79.8)755 (75.5)1283 (80.9)623 (78.6)2000 (83.7)966 (80.8)2509 (86.1)1260 (86.5)2294 (87.6)1133 (86.6)751 (85.7)371 (84.7)
Missing62 (3.1)11 (1.1)29 (1.8)6 (0.8)47 (2.0)9 (0.8)22 (0.8)9 (0.6)25 (1.0)8 (0.6)10 (1.1)3 (0.7)
Smoking
Never1089 (54.5)591 (59.1)778 (49.1)405 (51.1)1132 (47.4)590 (49.4)1271 (43.6)648 (44.5)1144 (43.7)550 (42.0)383 (43.7)182 (41.6)
Former581 (29.1)260 (26.0)563 (35.5)258 (32.5)946 (39.6)458 (38.3)1308 (44.9)648 (44.5)1220 (46.6)632 (48.3)410 (46.8)222 (50.7)
Current260 (13.0)130 (13.0)222 (14.0)124 (15.6)273 (11.4)130 (10.9)312 (10.7)145 (10.0)221 (8.4)109 (8.3)70 (8.0)31 (7.1)
Missing70 (3.5)19 (1.9)23 (1.5)6 (0.8)39 (1.6)17 (1.4)23 (0.8)16 (1.1)33 (1.3)18 (1.4)13 (1.5)3 (0.7)
Sleep duration (h)
< 7580 (29.0)313 (31.3)474 (29.9)281 (35.4)652 (27.3)347 (29.0)745 (25.6)392 (26.9)594 (22.7)314 (24.0)231 (26.4)98 (22.4)
7-91274 (63.7)625 (62.5)1025 (64.6)461 (58.1)1604 (67.1)782 (65.4)2043 (70.1)982 (67.4)1880 (71.8)923 (70.5)610 (69.6)320 (73.1)
> 964 (3.2)39 (3.9)48 (3.0)37 (4.7)72 (3.0)42 (3.5)90 (3.1)63 (4.3)102 (3.9)55 (4.2)23 (2.6)11 (2.5)
Missing82 (4.1)23 (2.3)39 (2.5)14 (1.8)62 (2.6)24 (2.0)36 (1.2)20 (1.4)42 (1.6)17 (1.3)12 (1.4)9 (2.1)
BMI (kg/m2)31.3 ± 6.731.2 ± 6.731.8 ± 6.632.0 ± 6.331.0 ± 6.131.3 ± 5.630.8 ± 5.530.9 ± 5.130.6 ± 5.530.6 ± 5.129.8 ± 4.930.1 ± 4.9
Cholesterol (mmol/L)4.67 ± 1.014.62 ± 1.114.63 ± 1.004.59 ± 1.084.59 ± 0.954.58 ± 1.064.58 ± 0.954.52 ± 1.054.68 ± 0.954.61 ± 1.044.71 ± 0.964.68 ± 1.06
HDL-C (mmol/L)1.24 ± 0.311.23 ± 0.331.21 ± 0.311.22 ± 0.331.24 ± 0.301.24 ± 0.311.24 ± 0.311.24 ± 0.301.27 ± 0.301.26 ± 0.311.29 ± 0.321.27 ± 0.31
LDL-C (mmol/L)2.83 ± 0.752.81 ± 0.832.79 ± 0.722.78 ± 0.782.75 ± 0.682.76 ± 0.782.72 ± 0.682.70 ± 0.762.80 ± 0.692.76 ± 0.772.83 ± 0.712.82 ± 0.78
Triglycerides (mmol/L)1.88 ± 1.281.92 ± 1.152.08 ± 1.472.07 ± 1.222.01 ± 1.372.00 ± 1.102.11 ± 1.412.10 ± 1.212.01 ± 1.212.02 ± 1.041.96 ± 1.191.98 ± 1.01
HbA1c (mmol/mol)36.6 ± 5.353.5 ± 16.6236.6 ± 5.052.8 ± 15.6237.0 ± 4.951.2 ± 13.8237.1 ± 5.349.4 ± 12.5237.3 ± 7.047.4 ± 10.9237.6 ± 10.345.5 ± 9.62
Hypertension1058 (52.9)528 (52.8)971 (61.2)480 (60.5)1486 (62.2)746 (62.4)1883 (64.6)930 (63.8)1707 (65.2)842 (64.3)547 (62.4)280 (63.9)
Heart disease200 (10.0)99 (9.9)177 (11.2)95 (12.0)314 (13.1)157 (13.1)481 (16.5)230 (15.8)447 (17.1)222 (17.0)158 (18.0)78 (17.8)
Depression162 (8.1)84 (8.4)129 (8.1)66 (8.3)146 (6.1)70 (5.9)190 (6.5)95 (6.5)127 (4.9)63 (4.8)24 (2.7)12 (2.7)