Minireviews
Copyright ©The Author(s) 2022.
World J Diabetes. Dec 15, 2022; 13(12): 1140-1153
Published online Dec 15, 2022. doi: 10.4239/wjd.v13.i12.1140
Table 1 Single nucleotide variations involving in the development of diabetic foot and its related complications
Ref.
Population or ethnicity
Total sample size (DF vs T2DM without DF) vs controls
Genes
SNVs reported
Potential influences of the SNVs on DF and DF related complications
Genotypes as risk or protective factors
Wang et al[17], 2020 Chinese2995 (681 vs 1053 vs 1261)CRPrs11265260Risk factor of DFOGG + AG/GG
CRPrs1800947Risk factor of DFO GG + CG
CRPrs2794520Risk factor of DFO TT + CT/TT
CRPrs1130864Risk factor of DFO TT + CT/TT
CRPrs3093059Protective factor against DFOCC+CT/CC
Dhamodharan et al[23], 2015 Indian515 (2701 vs 139 vs 106)IL-6rs1800795Protective factor against T2DM but not against DFU-DNGC, CC
Erdogan et al[24], 2017 Turkish204 (50 vs 35 vs 119)IL-6rs1800795Risk factor of T2DM but not DFUGG
Viswanathan et al[25], 2018 Indian270 (without controls)IL-6rs1800795Risk factor of severe wound infectionsGC + CC
Dhamodharan et al[23], 2015Indian515 (2701 vs 139 vs 106)TNF-αrs1800629Risk factor of both T2DM and DFU-DNGA, AA
Viswanathan et al[25], 2018Indian270 (without controls)TNF-αrs1800629Risk factors of severe wound infections, ulcer grade of DFGA + AA
rs361525Risk factor of ulcer grade of DF GA + AA
Dhamodharan et al[23], 2015Indian515 (2701 vs 139 vs 106)SDF-1rs1801157Protective factor against T2DM and/or DFU-DNGA, AA: T2DM; AA: DFU-DN
Viswanathan et al[25], 2018Indian270 (without controls)SDF-1rs1801157Risk factors of severe wound infections and major amputations (foot/leg)GA + AA
Amoli et al[34], 2011 Iranian586 (247 vs 241 vs 98)VEGFrs699947Protective factor against DFU AA
Li et al[35], 2018 Chinese288 (97 vs 88 vs 103)VEGFrs699947Protective factor against DFU AC, AA
Li[36], 2018 Chinese229 (121 vs 108) (without healthy controls)VEGFrs2010963Protective factor against DFUCC
Teena et al[42], 2020 Indian400 (100 vs 150 vs 150)NRF2rs35652124Risk factors of DFUTT
Teena et al[43], 2021 Indian400 (100 vs 150 vs 150)NRF2rs182428269Protective factor against T2DM and DFUCC, CT
Risk factor of T2DM and DFUTT
Peng et al[45], 2018Chinese438 (142 vs 148 vs 148)SIRT1rs12778366Protective factor against T2DM and DF Allele C carriers
Cao et al[48], 2020 Chinese430 (128 vs 147 vs 155)ICAM1rs5498Protective factor against T2DM and DF GG
ICAM1rs3093030Protective factor against DF CT + TT
Li[36], 2018 Chinese229 (121 vs 108) (without healthy controls)MCP-1rs1024611Risk factor of DFU GG
Su et al[51], 2018 Chinese400 (116 vs 135 vs 149)MCP-1rs1024611Risk factor of DFUAG, GG
Sadati et al[53], 2018 Iranian257 (123 vs 134) (without healthy controls)eNOSeNOS Glu298AspProtective factor against DFUTT
Erdogan et al[37], 2018 Turkish182 (50 vs 57 vs 75)eNOSeNOS G894TRisk factor of T2DM but not DFUNot related to DFU onset
Zubair and Ahmad[58], 2018 Arabian150 (50 vs 50 vs 50)HSP-70rs2227956Risk factor of DFU TT
Protective factor of DFUCC
Pichu et al[60], 2015 Indian224 (79 vs 79 vs 66)HIF-1αrs11549465Risk factor of DFU but not T2DMCT
Pichu et al[61], 2018 Indian529 (199 vs 185 vs 145)HIF-1αrs11549467Risk factors of T2DM and DFUGA
Pichu et al[65], 2017 Indian906 (301 vs 305 vs 300)LOXrs1800449Risk factor of DFU but not T2DM AA
Mrozikiewicz-Rakowska et al[66], 2017 Polish670 (204 vs 299 vs 167)ITLN1rs2274907Risk factor of DF but not T2DMTT
Meng et al[68], 2017 Scottish3394 (699 vs 2695)MAPK14rs80028505Risk factor of DFUNot reported
Wifi et al[71], 2017 Egyptian90 (30 vs 30 vs 30)TLRsrs5743836Risk factor of DFU among T2DM patientsCT
Singh et al[70], 2013 Indian255 (125 vs 130) (DFU vs healthy controls)TLRsrs4986790Risk factor of DFUAG/GG + AG
TLRsrs4986791Risk factor of DFUTT/CT/CT + TT
TLRsrs11536858Risk factor of DFUGG/AG/GG + AG
TLRsrs1927914Risk factor of DFUCC
TLRsrs1927911Risk factor of DFUCT/CT + TT
Nehring et al[72], 2013 Polish877 (122 vs 293 vs 462)OPGrs2073617Protective factor against DF among female patientsAG
OPGrs2073618Risk factor of DF among T2DM patientsCC
Soroush et al[76], 2017 Iranian212 (105 vs 107) (without healthy controls)VDRrs2228570Risk factor of DFU among T2DM patientsTT + CT
Zhao et al[78], 2015Chinese300 (123 vs 97 vs 80)FIBrs6056Risk factor of DFCT, TT