Case Control Study
Copyright ©The Author(s) 2019.
World J Diabetes. Jan 15, 2019; 10(1): 47-56
Published online Jan 15, 2019. doi: 10.4239/wjd.v10.i1.47
Table 1 Demographic, anthropometric and clinical characteristics of the study subjects n (%)
VariablesDM, n = 85HC, n = 85P-value
Age (yr)
mean ± SD161.7 ± 11.160.9 ± 10.30.620
< 50 yr11 (12.9)11 (12.9)0.965
50-59 yr25 (29.4)27 (31.8)
60-69 yr22 (25.9)23 (27.1)
≥ 70 yr27 (31.8)24 (28.2)
Gender
Male44 (51.8)44 (51.8)1.000
Female41 (48.2)41 (48.2)
Height (m)11.66 ± 0.081.65 ± 0.080.473
Weight (Kg)171.3 ± 13.665.4 ± 11.50.003
BMI (Kg/m2)1
mean ± SD126.0 ± 5.324.1 ± 4.30.010
Underweight3 (3.5)4 (4.7)0.072
Normal BMI35 (41.2)51 (60.0)
Overweight31 (36.5)21 (24.7)
Obese16 (18.8)9 (10.6)
Systolic BP (mmHg)1129.8 ± 20.7131.9 ± 24.30.557
Diastolic BP (mmHg)184.2 ± 11.582.8 ± 13.10.404
Total cholesterol (mmHg)14.904.780.622
FBG (mmol/L)17.00 ± 2.165.15 ± 0.060.001
HbA1C in % (mean ± SD)8.69 ± 2.46--
Duration of DM in months median (range)48.0 (0.3-312)--
Peripheral neuropathy51 (60)--
Table 2 Comparison of median nerve cross-sectional area between diabetics and healthy controls
Median nerve CSA (mm2)DM, n = 85HC, n = 85P-value
RightCarpal tunnel12.5 ± 2.58.8 ± 1.7< 0.01
5 cm proximal8.0 ± 2.05.3 ± 1.2< 0.01
LeftCarpal tunnel12.3 ± 2.58.6 ± 1.7< 0.01
5 cm proximal7.9 ± 1.95.4 ± 1.4< 0.001
Table 3 Comparison of median nerve cross-sectional area between diabetics with and diabetics without diabetic peripheral neuropathy
Median nerve CSA (mm2)Diabetic peripheral neuropathy
P-value
Absent n = 34Present n = 51
Carpal tunnel11.8 ± 2.412.9 ± 2.50.049
5cm Proximal8.0 ± 2.28.0 ± 2.00.856
Table 4 Comparison of median nerve cross-sectional area between diabetics without diabetic peripheral neuropathy, diabetics with mild diabetic peripheral neuropathy and diabetics with moderate/severe diabetic peripheral neuropathy
Median nerve CSA (mm2)Peripheral neuropathy
P-value
Absent (n = 34)Mild (n = 32)Moderate/severe (n = 19)
Carpal tunnel11.8 ± 2.4a13.2 ± 2.6a12.3 ± 2.1a0.062
5 cm Proximal7.9 ± 2.2b8.3 ± 2.2b7.6 ± 1.4b0.145
Table 5 Comparison of median nerve cross-sectional area between categories of age, gender, duration of diabetes mellitus, and glycemic control at carpal tunnel and 5 cm proximal to the carpal tunnel
Median nerve CSA (mm2) at CATL
DM_nonDPNP-valueDM_DPNP-valueHCP-value
Duration of DM≤ 5 yr11.4 ± 1.80.6512.9 ± 2.40.99--
> 5 yr11.8 ± 3.312.9 ± 2.7-
FBG≤ 7 mmol/L11.6 ± 2.30.7913.2 ± 2.90.34--
> 7 mmol/L11.4 ± 2.012.5 ± 1.8-
HBA1c≤ 7%11.0 ± 1.80.4512.3 ± 2.40.20--
> 7%11.7 ± 2.313.2 ± 2.6-
Age≤ 60 yr11.1 ± 1.90.2512.9 ± 2.31.008.7 ± 1.50.37
> 60 yr12.0 ± 2.412.9 ± 2.78.4 ± 1.9
SexFemale11.3 ± 1.90.6213.2 ± 2.60.428.1 ± 1.20.02
Male11.7 ± 2.412.6 ± 2.49.0 ± 2.0
Median nerve CSA (mm2) at 5cmCATL
DM_nonDPNP-valueDM_DPNP-valueHCP-value
Duration of DM≤ 5 yr7.6 ± 1.90.877.7 ± 1.70.13--
> 5 yr7.5 ± 1.58.5 ± 2.2-
FBG≤ 7 mmol/L7.5 ± 1.30.748.2 ± 1.90.57--
> 7 mmol/L7.7 ± 2.57.9 ± 2.0-
HBA1c≤ 7%7.5 ± 1.40.867.7 ± 2.20.29--
> 7%7.6 ± 1.98.3 ± 1.8-
Age≤ 60 yr7.3 ± 1.50.328.4 ± 2.10.255.5 ± 1.20.79
> 60 yr7.9 ± 2.27.8 ± 1.85.4 ± 1.5
SexFemale7.0 ± 1.40.107.8 ± 1.70.374.9 ± 0.70.00
Male8.0 ± 2.08.3 ± 2.25.9 ± 1.6
Table 6 Relationship between median nerve cross-sectional area on ultrasound and clinical/laboratory parameters of the diabetic subjects
VariablesCATL
5cmCATL
rP-valuerP-value
Age-0.0410.898-0.0500.650
Sex-0.05810.601-0.05010.651
Weight0.0940.390-0.0410.708
Height0.0420.7030.0250.817
BMI0.0910.407-0.0560.611
SBP-0.1260.2510.0500.648
DBP0.0430.6930.0500.648
TC0.0920.4020.0920.056
Duration of DM0.11020.3180.15120.167
FBG-0.0590.5910.0260.811
HbA1c-0.0120.9160.0340.758