Role of microRNA-7 in digestive system malignancy

Table 1 Expression of microRNA-7 in the digestive system

Cancer	Sample	Sap No.	Method	Exp	Role	Ref.
Colon	Stool	60	qPCR	↑	Diagnostic	[27]
CRC	Tissue	80	qPCR	↓	Diagnostic/therapeutic	[21]
CRC	Tissue	8	RT-PCR	↓	Therapeutic	[22]
CRC	Tissue	105	qRT-PCR	↑	Prognostic	[26]
ESCC	Tissue	34	Microarray/qRT-PCR	↑	Differentiation	[29]
GC	Tissue	40	ISH/IHC	↓	Inhibits metastasis/EMT	[18]
GC	Tissue	23	Microarray	↓	Inhibits invasion/metastasis	[19]
			qRT-PCR
GC	Tissue	28	RT-PCR	↓	Represses inflammation	[20]
HCC	Tissue	10	Microarray	-	Therapeutic/diagnostic/prognostic	[28]
			qRT-PCR
HCC	Tissue	12	qRT-PCR	↓	Tumor suppressor	[23]
HCC	Tissue	429	Chip assay	↓	Prognostic	[43]
CD	Tissue	-	RT-PCR	↓	Therapeutic	[25]

↓: MiR-7 is downregulated; ↑: MiR-7 is upregulated; −: There is no alteration for expression of miR-7, or no mention. Sap No.: Sample number; Exp: Expression; ISH/IHC: In situ hybridization/immunohistochemistry; CRC: Colorectal cancer; GC: Gastric cancer; HCC: Hepatocellular carcinoma; ESCC: Esophageal squamous cell carcinoma; EMT: Epithelial–mesenchymal transition; qPCR: Quantitative polymerase chain reaction.

Table 2 Function of microRNA-7 by targeting diverse genes

Cells	Function of miR-7	Target	Ref.
CCA	Reduces migration, invasion and metastasis	LAT1	[41]
CRC	Inhibits proliferation, invasion and metastasis, and induces G1 arrest	PAX6	[21]
CRC	Inhibits proliferation and induces apoptosis	XRCC2	[22]
CRC	Suppresses proliferation, induces G1 arrest, and induces apoptosis	YY1	[37]
GC	Suppresses invasion and metastasis	IGF1R	[18]
GC	Inhibits proliferation, invasion and metastasis	EGFR	[19]
HCC	Decreases invasion and migration	PIK3CD/mTOR/p70S6K	[28]
HCC	Suppresses colony formation and induces cell cycle arrest	CUL5	[23]

CCA: Cholangiocarcinoma; CRC: Colorectal cancer; GC: Gastric cancer; HCC: Hepatocellular carcinoma; miR-7: MicroRNA; XRCC2: X-ray repair complementing defective repair in Chinese hamster cells 2; IGF1R: Insulin-like growth factor 1 receptor; EGFR: Epidermal growth factor receptor; mTOR: Mammalian target of rapamycin; CUL5: Cullin 5.