Tumor neoangiogenesis detection by confocal laser endomicroscopy and anti-CD105 antibody: Pilot study

Table 1 Patient characteristics

Patient	Gender	Age	Tumor grading	Preoperative stage	RT	CTX
1	F	67	G1	T3N0M0	No	No
2	M	65	G2	T3N0M0	Neoadj	No
3	M	47	G2	T3N0M0	Neoadj	No
4	M	66	G2	T4N0M0	Adj	Adj
5	M	54	G2	T3N0M0	No	No
6	M	67	G1/G2	T3N1M0	Neoadj	Neoadj
7	F	80	G1 + Mucinous areas	T3N0M0	Neoadj	Neoadj
8	F	78	G2	T3N2M0	Neoadj	No
9	M	59	G1	T3N1M0	No	No
10	M	69	G1/G2	T3N0M0	Neoadj	No

RT: Radiotherapy; CTX: Chemotherapy; Neoadj: Neoadjuvant therapy; Adj: Adjuvant therapy; F: Female; M: Male.

Table 2 Quantitative results of vascular parameters from confocal laser endomicroscopy images

	CD31		CD105	P-value
Vascular	Normal	7.67 ± 0.5	3.46 ± 1.5	0.01
Diameter	Tissue
(μm)	Tumor	10.88 ± 0.8	10.97 ± 0.6	0.9
Vascular	Normal	3191.6 ± 387.8	244.21 ± 130.7	< 0.001
Density	Tissue
(vessels/mm3)	Tumor	4707.3 ± 448.8	2787.4 ± 133.8	0.001