Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions

Table 1 Polymorphisms reported on the associations with gastric atrophy among Helicobacter pylori seropositives as well as odds ratio and/or gastric atrophy percent.

Polymorphism	Function	Rs No.	Subjects [Ref.]	OR and/or GA%
IL-1B C-31T	5'UTR	rs1143627	253 Japanese[104]	CC (54%),CT (52%),TT (56%)
IL-1B C-31T	5'UTR	rs1143627	455 Jpn.Brazil.[59]	CC, CT: 0.61,TT: 0.58 CC (36%), CT (31%), TT (21%)
IL-1B C-31T	5'UTR	rs1143627	1328Venezuelan[94]	TT, CT: 1.01, CC: 0.91
IL-2 T-330G	5'UTR	rs2069762	244 Japanese[52]	GG ,TG: 1.64, TT: 2.78 aGG (38%), TG (50%), TT (62%)
IL-4 C-33T	5'UTR	rs2070874	249 Japanese[52]	CC, CT: 2.47, TT: 1.80 CC (38%), CT (60%), TT (53%)
IL-4 T-590C	5'UTR	rs2243250	1301 Venezuelan[53]	TT, CT: 0.82, CC: 0.81
IL-4R C-3223T	5'UTR	rs2057768	1301 Venezuelan[53]	CC, CT: 0.97, TT: 1.01
IL-4R A398G	Non-synonymous (Ile50Val)	rs1805010	1301 Venezuelan[53]	AA, AG: 1.14, GG: 1.52a
IL-6 G-174C	5'UTR	rs1800795	1315 Venezuelan[94]	GG, CG: 0.98, CC: 0.57
IL-8 T-251A	5'UTR	rs4073	1347 Venezuelan[94]	TT, AT: 0.98, AA: 1.07
IL-10 G-1082A	5'UTR	rs1800896	1301 Venezuelan[53]	GG, AG: 1.05, AA: 1.14
IL-13 C-1111T	5'UTR	rs1800925	248 Japanese[52]	CC, CT+TT: 0.41 aCC (59%), CT+TT (45%)
TNF-A T-1031C	5'UTR	rs4647198	455 Jpn.Brazil.[105]	CC (29%),TC (33%), TT (34%)
TNF-A C-857T	5'UTR	rs1799724	456 Jpn.Brazil.[105]	CC (32%), CT (36%), TT (39%)
TNF-A-1031&-857	5'UTR	rs1799724	455 Jpn.Brazil.[105]	CC&CC (29%), TT&CC (33%), TC&CT (43%), TT&TT (39%)
TNF-A G-308A	5'UTR	rs1800629	1327 Venezuelan[106]	GG, AG+AA: 1.27
MCP1 G-2518A	5'UTR	rs1024611	1311 Venezuelan[94]	AA, AG: 1.02, GG: 1.18
PTPN11 G/A at intron3	Intron	rs2301756	248 Japanese[46]	GG, GA: 0.70, AA: 0.09 aGG (59%),GA (49%),AA (11%)
PTPN11 G/A at intron3	Intron	rs2301756	979 Japanese[47]b	GG, GA+AA: 0.62c aGG (22%),GA+AA (15%)c
NOD1 G796A	Non-synonymous (Glu266Lys)	rs2075820	150 Turks[48]e	GG, GA: 13.35a, AA: 34.2a
TLR4 A+896G	Non-synonymous (Asp299Gly)	rs4986790	103 Caucasians[49]	AA, AG: 11.0* AA (36%), AG (87%)d
TLR4 A+896G	Non-synonymous (Asp299Gly)	rs4986790	717 Venezuelan[94]	GlyGly/AspGly, AspAsp: 1.53
TLR4 G+3725C	3'UTR	rs11536889	980 Japanese[50]b	GG, GC+CC: 1.33 GG( 18%), GC+CC (22%)c
CD14 C-159T(C-260T)	5'UTR	rs2569190	717 Venezuelan[94]	CC, CT+TT: 1.06
PRKCH rs3783799 G/A	Intron	rs3783799	1638 Japanese[54]	GG, GA: 0.99, AA: 2.37a
iNOS C150T	Non-synonymous (Ser608Leu)	rs2297518	250 Japanese[55]	CC, CT+TT: 0.75
RUNX3 T/A at intron3	Intron	rs760805	938 Japanese[56]b	TT, TA: 1.51a, AA:1.59a TT(46%), TA (56%), AA (56%)
HSP70-2 A/B (A1267G)	Synonymous (Gln351Gln)	rs1061581	137 Japanese[57]	BB (45%), AA+AB (67%)c
FAS G-1377A	5'UTR	rs2234767	109 Taiwanese[85]	No association
FAS A-670G	5'UTR	rs1800682	109 Taiwanese[85]	No association
FASL T-844C	5'UTR	rs763110	109 Taiwanese[85]	TT, TC+CC: 9.4a
PGC Ins/Del	Ins/Del	(unknown)	86 Chinese[68]	DD (90%), others (50%)a
NQO1 C609T	Non-synonymous (Pro187Ser)	rs1800682	396 Japanese[95]	TT, CT: 1.25, CC: 1.23
GSTM1	Ins/Del	(unknown)	396 Japanese[95]	Null, Present: 1.35
GSTT1	Ins/Del	rs71748309	396 Japanese[95]	Null, Present: 0.87
ACE Ins/Del	Ins/Del	rs1799752	271 Japanese[107]	II, ID: 1.12, DD: 0.99
RANTES C-471T	5'UTR	rs2107538	344 Germans[108]	No association
SDHC JST173800 C/G	3'UTR	rs3813632	249 Japanese[109]	CC, GC: 1.26, GG: 0.51 CC (53%), GC (59%), GG (38%)
IFNGR1 G-611A	5'UTR	rs1327474	805 Portuguese[110]	GG, GA: 1.2, AA: 1.2
IFNGR1 C-56T	5'UTR	rs2234711	814 Portuguese[110]	CC, CT: 1.4, TT: 1.3

^aStatistically significant (P< 0.05); ^bNumber ofH. pyloriinfected subjects (H. pyloriseropositive subjects or subjects with gastric atrophy); ^cOR for/percentages of subjects with severe gastric atrophy; ^dThere was no subject with GG genotype; ^eCagA-positive subjects,H. pylori:Helicobacter pylori; GA: Gastric atrophy; OR: Odds ratio.