Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions

doi:10.4251/wjgo.v2.i10.369

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 2, Issue 10

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (4875)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-3) series, Tables (1-1) series.

Item

Count

PDF

453

HTML

4117

Figures (1-3)

152

Tables (1-1)

153

Sum=4875

Oct 15, 2010 (publication date) through Apr 26, 2024

Times Cited of This Article

Times Cited (20)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Editorial

World J Gastrointest Oncol. Oct 15, 2010; 2(10): 369-379
Published online Oct 15, 2010. doi: 10.4251/wjgo.v2.i10.369

Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions

Asahi Hishida, Keitaro Matsuo, Yasuyuki Goto, Nobuyuki Hamajima

Asahi Hishida, Yasuyuki Goto, Nobuyuki Hamajima, Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan

Keitaro Matsuo, Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan

Author contributions: Hishida A wrote the entire manuscript; Matsuo K and Goto Y critically checked the manuscript; and Hamajima N supervised the whole project.

Supported by A Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology.

Correspondence to: Asahi Hishida, MD, PhD, Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. a-hishi@med.nagoya-u.ac.jp

Telephone: +81-52-7442132 Fax: +81-52-7442971

Received: March 29, 2010
Revised: September 20, 2010
Accepted: September 27, 2010
Published online: October 15, 2010

Abstract

Gastric cancer is the most common malignancy of the gastrointestinal tract in East Asian populations and the second most frequent cause of cancer-related mortality in the world. While previous studies have investigated the genetic factors involved in gastric carcinogenesis, there still exist relatively few studies that have investigated the genetic traits associated with the risk of gastric precancerous conditions. In this paper we will review the biology and genetic polymorphisms involved in the genesis of gastric precancerous conditions reported to date and discuss the future prospects of this field of study. The associations of gastric precancerous conditions with polymorphisms in the cytotoxin-associated gene A-related genes (e.g. PTPN11 G/A at intron 3, rs2301756), those in the genes involved in host immunity against Helicobacter pylori (H. pylori) infection (e.g. TLR4 +3725G/C, rs11536889) or polymorphisms of the genes essential for the development/ differentiation of the gastric epithelial cells (e.g. RUNX3 T/A polymorphism at intron 3, rs760805) have been reported to date. Genetic epidemiological studies of the associations between H. pylori-induced gastric precancerous conditions and other gene polymorphisms in these pathways as well as polymorphisms of the genes involved in other pathways like oxidative DNA damage repair pathways would provide useful evidence for the individualized prevention of these H. pylori-induced gastric precancerous conditions.

Keywords: Helicobacter pylori, Gastric cancer, Single nucleotide polymorphisms, Genetic predisposition to disease, Gastric precancerous conditions