Integrating traditional Chinese medicine with pancreatic cancer organoids: Bibliometric insights and translational perspectives

Table 1 General bibliometric characteristics of the included publications on pancreatic cancer organoids (2001-2026)

Indicator	Value
Total number of included studies	1066
Research article	901
Review	165
Time span	2001-2026
Number of countries/regions involved	58
Sum of times cited	42356
Average citations per Item	39.73
H-index	92
Countries with the most publications	United States
Institutions with the most publications	Harvard University

Table 2 Top 15 countries based on comprehensive indicators

Rank	Country	Documents	Citations	Average citations	Norm citations	Links	Total link strength
1	United States	404	23422	57.98	492.40	32	299
2	China	218	4833	22.17	220.65	21	112
3	Germany	166	5891	35.49	160.94	27	185
4	Japan	90	3064	34.04	81.79	17	45
5	Italy	80	4813	60.16	95.28	24	99
6	Netherlands	65	10940	168.31	119.01	18	80
7	England	64	4444	69.44	92.54	23	97
8	South Korea	56	1244	22.21	50.07	7	18
9	France	55	2137	38.85	49.66	16	49
10	Spain	53	3532	66.64	57.99	19	84
11	Canada	36	2670	74.17	46.16	15	48
12	Sweden	24	3068	127.83	44.80	16	41
13	Australia	22	808	36.73	25.21	15	38
14	Switzerland	20	2205	110.25	26.09	14	33
15	Denmark	18	454	25.22	19.05	12	26

Table 3 Top 15 institutions based on comprehensive indicators

Rank	Institutions	Documents	Citations	Average citations	Total link strength
1	Harvard Med Sch	52	2786	53.58	121
2	Cold Spring Harbor Lab	36	8015	222.64	95
3	Johns Hopkins Univ	32	3989	124.66	74
4	German Canc Res Ctr	27	962	35.63	57
5	Tech Univ Munich	26	1142	43.92	54
6	Univ Nebraska Med Ctr	26	2325	89.42	48
7	Dana Farber Canc Inst	25	1716	68.64	88
8	Mem Sloan Kettering Canc Ctr	25	3996	159.84	74
9	Shanghai Jiao Tong Univ	25	782	31.28	31
10	Sun Yat Sen Univ	23	791	34.39	17
11	Chinese Acad Sci	22	715	32.50	40
12	Univ Verona	22	2647	120.32	34
13	Fudan Univ	21	596	28.38	32
14	Aix Marseille Univ	20	508	25.40	17
15	Univ Calif San Diego	20	780	39.00	48

Table 4 Top 15 authors based on comprehensive indicators

Author	Documents	Citations	Average citations	Norm citations	Links	Total link strength
Tuveson, David A	24	4556	189.83	53.37	15	52
Kleger, Alexander	18	390	21.67	17.28	15	58
Corbo, Vincenzo	16	2306	144.13	29.26	17	48
Tiriac, Herve	15	3102	206.80	30.15	14	39
Batra, Surinder K	15	483	32.20	19.53	10	61
Seufferlein, Thomas	15	329	21.93	13.89	8	49
Clevers, Hans	14	6732	480.86	47.79	13	19
Ponnusamy, Moorthy P	13	462	35.54	18.37	10	61
Reichert, Maximilian	11	319	29.00	6.86	2	6
Hwang, Chang-il	10	2683	268.30	26.05	18	37
Rauth, Sanchita	10	246	24.60	15.12	10	55
Park, Youngkyu	9	3670	407.78	37.46	12	33
Muthuswamy, Senthil K	9	1097	121.89	18.57	4	20
Gout, Johann	9	185	20.56	8.34	8	34
Huang, Ling	8	1088	136.00	16.75	4	18

Table 5 Top 20 journals based on publication titles comprehensive indicators

Journal	Record count	% of 1066	IF	JCR
Cancers	56	5.25	4.4	Q2
Scientific Reports	26	2.44	3.9	Q1
International Journal of Molecular Sciences	25	2.35	4.9	Q1
Journal of Experimental Clinical Cancer Research	25	2.35	12.8	Q1
Clinical Cancer Research	24	2.25	10.2	Q1
Gastroenterology	22	2.06	25.9	Q1
Cancer Research	21	1.97	16.6	Q1
Nature Communications	21	1.97	15.7	Q1
Cancer Letters	20	1.88	10.1	Q1
Frontiers in Cell and Developmental Biology	19	1.78	4.3	Q2
Frontiers in Oncology	15	1.401	3.3	Q2
Advanced Science	13	1.22	14.1	Q1
Gut	13	1.22	26.2	Q1
Molecular Cancer Therapeutics	12	1.13	5.5	Q1
Advanced Healthcare Materials	11	1.03	9.6	Q1
Plos One	11	1.03	2.6	Q2
Cell Reports	10	0.94	6.9	Q1
Oncogene	10	0.94	7.3	Q1
Biomaterials	9	0.84	12.9	Q1
Cancer Discovery	9	0.84	33.3	Q1

Table 6 Top 25 high-frequency keywords

Keywords	Frequency	Centrality
Pancreatic cancer	279	0.76
Pancreatic ductal adenocarcinoma	102	0.21
Tumor microenvironment	47	0.13
Precision medicine	39	0.21
Personalized medicine	32	0.2
Nude mice	30	0.39
Patient-derived organoids	28	0.04
Drug screening	19	0.16
Salmonella typhimurium a1-r	18	0.13
3D culture	15	0.19
Pancreatic ductal adenocarcinoma (PDAC)	13	0.08
Patient-derived orthotopic xenograft	12	0.07
Cancer stem cells	11	0.1
Recombinant methioninase	9	0
Drug resistance	8	0
3D cell culture	7	0.02
Extracellular matrix	7	0.05
Precision oncology	7	0.01
Methionine dependence	6	0.01
Targeted therapy	6	0.05
Combination therapy	6	0.05
Patient-derived organoid	6	0
Three-dimensional culture	5	0.16
Kras mutation	5	0
Stem cells	4	0

PDAC: Pancreatic ductal adenocarcinoma; 3D: Three-dimensional.

Table 7 Top 20 co-citation of references based on comprehensive indicators

Author	Year	Journal	Count of citations	Centrality
Tiriac et al[14]	2018	Cancer Discov	141	0.02
Boj et al[13]	2015	Cell	124	0.02
Seino et al[52]	2018	Cell Stem Cell	83	0.06
Raghavan et al[53]	2021	Cell	80	0.03
Driehuis et al[54]	2019	P Natl Acad SCI USA	80	0.04
Bailey et al[40]	2016	Nature	70	0.01
Öhlund et al[55]	2017	J Exp Med	61	0.14
Chan-Seng-Yue et al[41]	2020	Nat Genet	55	0.06
Halbrook et al[42]	2023	Cell	54	0
Tsai et al[43]	2018	Bmc Cancer	53	0.01
Huang et al[44]	2015	Nat Med	51	0.08
Hiroshima et al[45]	2014	Oncotarget	49	0.01
Vlachogiannis et al[56]	2018	Science	45	0.01
Cancer Genome Atlas Research Network[46]	2017	Cancer Cell	42	0
Siegel et al[47]	2021	Ca-Cancer J Clin	41	0
Murakami et al[48]	2016	Oncotarget	41	0.01
Metildi et al[49]	2014	J Surg Oncol	40	0.01
Drost et al[50]	2018	Nat Rev Cancer	40	0
Neal et al[57]	2018	Cell	40	0.01
Baker et al[51]	2016	Trends Cancer	39	0

Table 8 Top 20 co-citation of journals based on comprehensive indicators

Journal	Count of citations	Centrality
Cell	747	0.08
Cancer Res	735	0.26
P Natl Acad SCI USA	679	0.05
Nature	659	0.06
Clin Cancer Res	624	0.06
Cancer Cell	546	0.11
Nat Commun	546	0.00
Cancer Discov	504	0.01
Science	487	0.40
Gastroenterology	485	0.02
Plos One	483	0.02
SCI Rep-UK	475	0.01
Nat Med	474	0.13
Nat Rev Cancer	465	0.30
New Engl J Med	404	0.04
Oncotarget	400	0.00
Cancers	380	0.05
Ca-Cancer J Clin	373	0.00
Oncogene	355	0.04
Brit J Cancer	340	0.01

Table 9 Top 20 highly coupled documents based on comprehensive indicators

Ref.	Journal	Title	Year	Citations	Total link strength	Cluster	Research theme
Tiwari et al[68]	Journal of Biomedical Science	Tumor Microenvironment: Barrier or Opportunity towards Effective Cancer Therapy	2022	290	427	1	Tumor microenvironment; Organoids
Chen et al[71]	Cancer Cell	Oncogenic Collagen i Homotrimers from Cancer Cells Bind to α3β1 Integrin and Impact Tumor Microbiome and Immunity to Promote Pancreatic Cancer	2022	216	188	2	Mechanisms of resistance in pancreatic cancer
Mahadevan et al[60]	Cancer Cell	KRAS G12D Inhibition Reprograms the Microenvironment of Early and Advanced Pancreatic Cancer to Promote Fas-mediated Killing by CD8+ T Cells	2023	182	432	2	Mechanisms of resistance in pancreatic cancer
Dilly et al[72]	Cancer Discovery	Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer	2024	177	506	2	Mechanisms of resistance in pancreatic cancer
Mucciolo et al[62]	Cancer Cell	EGFR-activated Myofibroblasts Promote Metastasis of Pancreatic Cancer	2024	156	476	1	Tumor microenvironment; Organoids
Schuth et al[58]	Journal of Experimental & Clinical Cancer Research	Patient-specific Modeling of Stroma-mediated Chemoresistance of Pancreatic Cancer Using A Three-dimensional Organoid-fibroblast Co-culture System	2022	131	643	6	Pancreatic cancer organoids
Magré et al[73]	Journal for Immunotherapy of Cancer	Emerging Organoid-immune Co-culture Models for Cancer Research: From Oncoimmunology to Personalized Immunotherapies	2023	131	362	1	Tumor microenvironment; Organoids
Goodwin et al[74]	Cancer Research	Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-mutant Pancreatic Cancer	2023	125	195	2	Mechanisms of resistance in pancreatic cancer
Proietto et al[65]	Frontiers in Oncology	Tumor Heterogeneity: Preclinical Models, Emerging Technologies, and Future Applications	2023	121	438	1	Tumor microenvironment; organoids
Haque et al[75]	Microsystems & Nanoengineering	Patient-derived Pancreatic Cancer-on-a-chip Recapitulates the Tumor Microenvironment	2022	113	260	1	Tumor microenvironment; organoids
Su et al[67]	Science Translational Medicine	Targeting SRC Reactivates Pyroptosis to Reverse Chemoresistance in Lung and Pancreatic Cancer Models	2023	113	14	1	Tumor microenvironment; organoids
Müller et al[63]	Cell Death and Differentiation	Elevated FSP1 Protects KRAS-mutated Cells from Ferroptosis during Tumor Initiation	2023	108	206	2	Mechanisms of resistance in pancreatic cancer
Schwörer et al[66]	Cancer Research	Hypoxia Potentiates the Inflammatory Fibroblast Phenotype Promoted by Pancreatic Cancer Cell-derived Cytokines	2023	107	318	1	Tumor microenvironment; organoids
Grossman et al[59]	Clinical Cancer Research	Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer	2022	104	614	3	Molecular mechanisms of pancreatic cancer
Matthews et al[61]	Plos Computational Biology	Organoid: A Versatile Deep learning Platform for Tracking and Analysis of Single-organoid Dynamics	2022	102	45	1	Tumor microenvironment; organoids
Braxton et al[76]	Nature	3D Genomic Mapping Reveals Multifocality of Human Pancreatic Precancers	2024	97	111	3	Molecular mechanisms of pancreatic cancer
Suarez-Martinez et al[6]	Cell and Bioscience	3D and Organoid Culture in Research: Physiology, Hereditary Genetic Diseases and Cancer	2022	96	569	1	Tumor microenvironment; organoids
Wehrli et al[70]	Clinical Cancer Research	Mesothelin CAR T Cells Secreting Anti-fap/anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and Its Stroma	2024	94	392	1	Tumor microenvironment; organoids
Nelson et al[64]	Nature Communications	USP25 Promotes Pathological HIF-1-driven Metabolic Reprogramming and Is A Potential Therapeutic Target in Pancreatic Cancer	2022	94	387	3	Molecular mechanisms of pancreatic cancer
Wang et al[69]	Cancer Research	Mitochondrial Calcium Uniporter Drives Metastasis and Confers A Targetable Cystine Dependency in Pancreatic Cancer	2022	90	109	2	Mechanisms of resistance in pancreatic cancer