Associations between blood metabolite levels and gastrointestinal cancer risk: A preliminary untargeted metabolomics study

doi:10.4251/wjgo.v17.i7.104860

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Jul 15, 2025 (publication date) through Jul 14, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastrointest Oncol. Jul 15, 2025; 17(7): 104860
Published online Jul 15, 2025. doi: 10.4251/wjgo.v17.i7.104860

Table 1 The demographic and clinical biochemical indicators of participants

Parameters	GC (n = 30)	CRC (n = 30)	P value
Sex (M/F)	25/5	18/12	0.084
Age (year)	65.667 ± 9.586	67.533 ± 10.569	0.477
Height (cm)	167.200 ± 8.109	165.300 ± 8.619	0.398
Weight (kg)	68.333 ± 10.516	62.983 ± 10.185	0.026
BMI (kg/m²)	24.398 ± 2.943	23.074 ± 3.465	0.049
RBC (10¹²/L)	4.102 ± 0.573	4.082 ± 0.572	0.895
hemoglobin (g/L)	119.367 ± 22.890	114.533 ± 27.860	0.466
WBC (10⁹/L)	5.622 ± 1.448	6.548 ± 1.345	0.013
NEU (10⁹/L)	3.351 ± 1.047	4.349 ± 1.278	0.001
platelet (10⁹/L)	216.333 ± 63.992	253.900 ± 97.899	0.255
AST (U/L)	17.600 ± 4.394	19.400 ± 18.377	0.170
ALT (U/L)	15.867 ± 7.930	14.267 ± 9.089	0.139
Scr (μmol/L)	74.353 ± 14.962	104.697 ± 167.425	0.756
BUN (mmol/L)	5.452 ± 1.495	6.018 ± 2.399	0.595
CEA (ng/mL)	14.505 ± 48.041	30.936 ± 67.325	0.000
CA-199 (U/mL)	128.862 ± 337.614	45.717 ± 161.795	0.935
AFP (ng/mL)	11.253 ± 41.291	2.740 ± 1.061	0.234
CA-125 (U/mL)	12.204 ± 8.790	16.466 ± 16.454	0.511
CA-153 (U/mL)	7.557 ± 3.163	8.619 ± 5.258	0.610

CRC: Colorectal cancer; GC: Gastric cancer; BMI: Body mass index; RBC: Red blood cell count; WBC: White blood cell count; NEU: Neutrophil count; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; Scr: Serum creatinine; BUN: Blood urea nitrogen; CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; AFP: Α-fetoprotein; M: Male; F: Female.

Table 2 Statistical table of different metabolites

Groups	Differential metabolites number	Upregulated metabolites number	Downregulated metabolites number
A: CRC vs normal	455	234	221
B: GC vs normal	459	251	208
C: CRC vs GC	187	91	96

CRC: Colorectal cancer; GC: Gastric cancer.

Citation: Guo TH, Zhu WJ, Hui YF, Zhao SQ, Zhou TT, Wang XM, Zhang QC, Wang W, Li L, Shen WX, Wu XY, Cheng HB. Associations between blood metabolite levels and gastrointestinal cancer risk: A preliminary untargeted metabolomics study. World J Gastrointest Oncol 2025; 17(7): 104860
URL: https://www.wjgnet.com/1948-5204/full/v17/i7/104860.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i7.104860