Factors associated with heterochronic gastric cancer development post-endoscopic mucosal dissection in early gastric cancer patients

Table 1 Basic information about the study patients

	Age (yr)	Body mass index (kg/m2)	White blood cell count (× 109/L)	Platelet count (× 109/L)	Admission creatinine (mg/dL)
Patients	61.31 ± 9.60	24.68 ± 3.36	14.57 ± 3.40	169.55 ± 49.70	0.94 (0.70, 1.20)
t/Z/χ2 values	0.78	0.82	0.41	2.09	1.50
P value	> 0.05	> 0.05	> 0.05	< 0.05	> 0.05

Table 2 Logistics regression analysis of risk factors for multiple gastric cancers after endoscopic submucosal dissection

Clinical and lesion characteristics	OR	95%CI	P value
Age ≥ 65 yr	1.902	0.435-8.328	0.393
Male	1.435	0.383-5.382	0.592
Smoking (BI ≥ 400)	2.697	0.707-10.290	0.146
Lesion in the lower third of the stomach	11.280	2.720-46.775	0.001
O-shaped atrophy	1.547	0.372-6.442	0.549
Severe intestinalization	6.206	1.667-23.109	0.006
Divergent	9.178	1.642-51.305	0.012

95%CI: 95% confidence interval; OR: Odds ratio; BI: Brinkman index.

Table 3 Univariate analysis of risk factors for developing concurrent gastric cancer

Clinicopathological features	OR	95%CI	P value
Age ≥ 65 yr	5.679	1.164-27.701	0.025
Male	2.400	0.600-9.604	0.343
Smoking (BI ≥ 400)	2.622	0.689-9.971	0.291
Family history of stomach cancer	3.067	0.291-32.329	0.359
Initial multiple foci	4.547	0.101-19.960	0.912
Lesion ≥ 2 cm	2.042	0.563-7.399	0.348
Lesion in the lower third of the stomach	2.469	0.620-9.830	0.220
O-shaped atrophy	2.115	0.531-8.425	0.447
Severe intestinalization	4.632	1.159-18.514	0.045
Divergent	6.25	0.771-50.695	0.109
Depth of submucosal infiltration < 500 μm	4.4	0.745-25.991	0.134

95%CI: 95% confidence interval; OR: Odds ratio; BI: Brinkman index.

Table 4 Logistics regression analysis of risk factors for the development of concurrent gastric cancer

Influencing factors	OR	95%CI	P value
Age ≥ 65 yr	2.458	0.404-14.958	0.329
Severe intestinalization	4.711	0.969-22.896	0.055

95%CI: 95% confidence interval; OR: Odds ratio.

Table 5 Univariate analysis of risk factors for the development of heterochronic gastric cancer

Clinicopathological features	OR	95%CI	P value
Age ≥ 65 yr	7.571	1.606-35.699	0.004
Male	5.400	1.146-25.446	0.022
Smoking (BI ≥ 400)	3.441	1.056-11.214	0.074
Family history of stomach cancer	5.111	0.774-33.752	0.123
Initial multiple foci	1.813	0.344-9.560	0.831
Lesion ≥ 2 cm	1.167	0.407-3.344	0.794
Lesion in the lower third of the stomach	7.778	1.690-35.795	0.034
O-shaped atrophy	3.437	0.924-12.784	0.061
Severe intestinalization	3.821	1.234-11.828	0.047
Divergent	9.375	1.192-73.735	0.037
Depth of submucosal infiltration < 500 μm	1.320	0.144-12.089	0.585

95%CI: 95% confidence interval; OR: Odds ratio; BI: Brinkman index.

Table 6 Logistics regression analysis of risk factors for the development of heterochronic gastric cancer

Influencing factors	OR	95%CI	P value
Age ≥ 65 yr	4.119	0.696-24.358	0.119
Male	4.205	0.882-20.057	0.072
Lesion in the lower third of the stomach	14.87	2.508-88.166	0.003
Severe intestinalization	4.484	1.029-19.536	0.046
Divergent	12.644	1.303-122.714	0.029

95%CI: 95% confidence interval; OR: Odds ratio.