Features of gastric cancer by anatomic subsite in northern China: A multi-center Health Science Report database study

Table 1 Summary of reported proportion of cardia and non-cardia (including body and antrum) cancer worldwide

Region		Ref.		Period		Anatomical site ratio (%)1
						Cardia	Non-Cardia
							Body	Antrum
East Asia	Northern China		This article		2014-2018	35.85%	19.24%	44.91%
	Southwest China		Liu et al[19], 2016		2008-2012	37.15%	10.30%	52.55%
	Northwest China		Zhou et al[18], 2008		1993-2004	35.78%	28.00%	36.22%
	Japan		Koizumi et al[11], 2018		2013-2015	9.82%	53.58%	36.60%
West Asia	Northwest Iran		Derakhshan et al[29], 2004		2000-2003	44.78%	26.19%	29.03%
North America	The USA		Camargo et al[7], 2011		1999-2007	41.41%	11.13%	47.46%
Europe	Central Switzerland		Schmassmann et al[26], 2009		1982-2007	26.02%	73.98%
	Spain		Aragonés et al[27], 2010		1980-2004	26.67%	73.33%
	Netherland		Holster et al[28], 2014		1973-2011	31.82%	30.30%	37.88%

¹Proportions of cardia and non-cardia (including body and antrum) were recalculated.

USA: United States.

Table 2 Clinical and hospitalizing features on gastric cancer patients based on anatomic site subgroups

Variables			Cardia (n = 3673)	Body (n = 1972)	Antrum (n = 4602)	P value
Clinical features	Basic information	Gender				< 0.001
		Male	3046 (82.93%)	1264 (64.10%)	3140 (68.23%)
		Female	627 (17.07%)	708 (35.90%)	1462 (31.77%)
		Age (yr)				< 0.001
		≤ 49	266 (7.24%)	479 (24.29%)	809 (17.58%)
		50-74	536 (78.16%)	158 (67.70%)	585 (69.71%)
		≥ 75	2871 (14.60%)	1335 (8.01%)	3208 (12.71%)
		Mean (mean ± SD)	63.98 ± 10.21 (63.65, 64.31)	57.57 ± 12.68 (57.04, 58.10)	60.32 ± 12.06 (59.97, 60.67)	< 0.001
		Patient source				< 0.001
		Urban	3000 (81.68%)	1633 (82.81%)	3969 (86.25%)
		Rural	673 (18.32%)	339 (17.19%)	633 (13.75%)
		Insurance Source				< 0.001
		MIUE	1499 (40.81%)	906 (45.94%)	2004 (43.55%)
		MIUR	179 (4.88%)	98 (4.97%)	205 (4.45%)
		NRCMI	673 (18.32%)	302 (15.31%)	627 (13.62%)
		Own expense	885 (24.09%)	476 (24.14%)	1121 (24.36%)
		Others	437 (11.90%)	190 (9.64%)	645 (14.02%)
	Complications	Hypertension				< 0.001
		No	2630 (71.60%)	1550 (78.60%)	3470 (75.40%)
		Yes	1043 (28.40%)	422 (21.40%)	1132 (24.60%)
		Diabetes				0.03
		No	3213 (87.48%)	1767 (89.60%)	4093 (88.94%)
		Yes	460 (12.52%)	205 (10.40%)	509 (11.06%)
		GERD				< 0.001
		No	3252 (88.54%)	1886 (95.64%)	4387 (95.33%)
		Yes	421 (11.46%)	86 (4.36%)	215 (4.67%)
		Cerebrovascular disease				0.01
		No	3488 (94.96%)	1895 (96.10%)	4430 (96.26%)
		Yes	185 (5.04%)	77 (3.90%)	172 (3.74%)
		Coronary disease				< 0.001
		No	3353 (91.29%)	1843 (93.46%)	4309 (93.63%)
		Yes	320 (8.71%)	129 (6.54%)	293 (6.37%)
		Obstruction				< 0.001
		No	3616 (98.45%)	1952 (98.99%)	4136 (89.87%)
		Yes	57 (1.55%)	20 (1.01%)	466 (10.13%)
		Anemia				0.009
		No	3451 (93.96%)	1811 (91.84%)	4274 (92.87%)
		Yes	222 (6.04%)	161 (8.16%)	328 (7.13%)
		Hypoproteinemia				0.005
		No	3566 (97.09%)	1882 (95.44%)	4428 (96.22%)
		Yes	107 (2.91%)	90 (4.56%)	174 (3.78%)
Hospitalization features		Admission route				0.007
		Emergency	100 (2.72%)	28 (1.42%)	101 (2.20%)
		Non-emergency	3573 (97.28%)	1944 (98.58%)	4501 (97.80%)
		Stay (d) (mean ± SD)	13.41 ± 12.17 (13.02, 13.80)	14.08 ± 12.24 (13.57, 14.59)	16.89 ± 12.24 (16.53, 17.24)	< 0.001

MIUE: Medical insurance for urban employees; MIUR: Medical insurance for urban residents; NRCMI: New rural cooperative medical insurance; GERD: Gastroesophageal reflux disease.