Synaptophysin-like 2 expression correlates with lymph node metastasis and poor prognosis in colorectal cancer patients

Table 1 Correlation between synaptophysin-like 2 level and clinicopathological characteristics in colorectal cancer

Characteristics	SYPL2 level		P value
	Low (n = 285)	High (n = 286)
Age (yr)	68.00 ± 12.14	65.31 ± 13.37	0.1148
Gender
Female	125	128	0.8273
Male	145	143
Unknow	20	15
T
T1 + T2	61	37	0.0140a
T3 + T4	179	192
Unknow	45	57
N
N0	153	123	0.0312a
N1-2	87	105
Unknow	45	56
M
M0	185	164	0.0955
M1	29	39
Unknow	71	83
AJCC stage
I-II	146	114	0.0228a
III-IV	88	106
Unknow	51	66

^aP < 0.05.

AJCC: American Joint Commission on Cancer; SYPL2: Synaptophysin-like 2.

Table 2 Cox regression analysis of synaptophysin-like 2 expression and clinical pathological characteristics

Characteristics	Univariate Cox			Multivariate Cox
	HR	95%CI	P value	HR	95%CI	P value
Age	1.037	1.015-1.059	0.0001a	1.051	1.027-1.075	0.0001a
Gender (male)	1.160	0.746-1.803	0.509	0.987	0.621-1.571	0.957
T
T1	1			1
T2	0.819	0.169-3.953	0.804	0.354	0.069-1.805	0.212
T3	1.324	0.322-5.456	0.697	0.424	0.096-1.863	0.256
T4	4.661	1.082-20.075	0.039a	0.906	0.189-4.348	0.901
N
N0	1			1
N1	2.547	1.484-4.368	0.0001a	1.988	1.048-3.770	0.035a
N2	4.195	2.479-7.099	0.0001a	2.253	1.179-4.304	0.014a
M (M1)	4.482	2.829-7.100	0.0001a	2.585	1.468-4.660	0.001a
ACJJ
I	1
II	1.474	0.548-3.961	0.442
III	2.858	1.086-7.627	0.033a
IV	8.096	3.135-20.903	0.0001a
SYPL2 (high)	2.078	1.162-3.716	0.014a	1.754	1.103-2.790	0.018a

^aP < 0.05.

AJCC: American Joint Commission on Cancer; SYPL2: Synaptophysin-like 2; HR: Hazards ratio; CI: Confidence interval.