Retrospective Study
Copyright ©The Author(s) 2021.
World J Gastrointest Oncol. Mar 15, 2021; 13(3): 161-173
Published online Mar 15, 2021. doi: 10.4251/wjgo.v13.i3.161
Table 1 Patient characteristics and clinicopathological findings

Group A (< 18.5 kg/m2)
Group B (18.5-24.9 kg/m2)
Group C (25-29.9 kg/m2)
Group D (≥ 30 kg/m2)
P value
Male sex, n (%)73 (61.3)1124 (77.1)713 (85.1)84 (75.0)< 0.001
Age < 65 yr, n (%)79 (66.4)1067 (73.2)615 (73.4)79 (70.5)0.384
Preoperative weight loss, n (%)< 0.001
0% or increased75 (63.0)1010 (63.9)623 (74.3)89 (79.5)
0-5%7 (5.9)127 (8.7)88 (10.5)10 (8.9)
> 5%37 (31.1)320 (22.0)127 (15.2)13 (11.6)
BMI, median (range)17.1 (14.0-18.4)22.5 (18.5-24.9)26.7 (25.0-29.9)31.2 (30.0-48.8)< 0.001
Diabetes, n (%)3 (2.5)100 (6.9)107 (12.8)22 (19.6)< 0.001
Tumor location0.044
Upper41 (34.5)481 (33.0)337 (40.2)46 (41.1)
Middle24 (20.2)294 (20.2)164 (19.6)24 (21.4)
Lower49 (41.2)604 (41.5)308 (36.8)38 (33.9)
Entire5 (4.2)78 (5.4)29 (3.5)4 (3.6)
Tumor diameter ≤ 5 cm, n (%)857 (71.4)1019 (69.9)603 (72.0)83 (74.1)0.642
Borrmann type, n (%)0.116
EGC26 (21.8)298 (20.5)181 (21.6)30 (26.8)
I8 (6.7)112 (7.7)55 (6.6)13 (11.6)
II30 (25.2)376 (25.8)247 (29.5)29 (25.9)
III53 (44.5)582 (39.9)317 (37.8)34 (30.4)
IV2 (1.7)89 (6.1)38 (4.5)6 (5.4)
Histological type, n (%)0.931
Differentiated31 (26.1)351 (24.1)201 (24.0)25 (22.3)
Undifferentiated88 (73.9)1106 (75.9)637 (76.0)87 (77.7)
PNI, n (%)48 (40.3)701 (48.1)419 (50.0)49 (43.8)0.177
LVI, n (%)41 (34.5)583 (40.0)322 (38.4)55 (49.1)0.105
pT status, n (%)0.606
1a13 (10.9)164 (11.3)78 (9.3)12 (10.7)
1b16 (13.4)216 (14.8)131 (15.6)21 (18.8)
218 (15.1)202 (13.9)119 (14.2)18 (16.1)
338 (31.9)434 (29.8)280 (33.4)34 (30.4)
4a29 (24.4)401 (27.5)198 (23.6)23 (20.5)
4b5 (4.2)40 (2.7)32 (3.8)4 (3.6)
pN status, n (%)0.143
050 (42.0)593 (40.7)344 (41.1)45 (40.2)
122 (18.5)276 (18.9)163 (19.5)18 (16.1)
218 (15.1)238 (16.3)137 (16.3)27 (24.1)
3a21 (17.6)169 (11.6)116 (13.8)13 (11.6)
3b8 (6.7)181 (12.4)78 (9.3)9 (8.0)
pTNM stage, n (%)0.261
IA24 (20.2)307 (21.1)173 (20.6)29 (25.9)
IB10 (8.4)156 (10.7)88 (10.5)9 (8.0)
IIA17 (14.3)185 (12.7)99 (11.8)15 (13.4)
IIB19 (16.0)202 (13.9)127 (15.2)14 (12.5)
IIIA20 (16.8)253 (17.4)154 (18.4)21 (18.8)
IIIB22 (18.5)173 (11.9)124 (14.8)15 (13.4)
IIIC7 (5.9)181 (12.4)73 (8.7)9 (8.0)
eLNs, median (range)30 (7-65)30 (3-119)28 (5-89)27 (4-71)0.008
mLN, median (range)1 (0-24)1 (0-67)1 (0-48)2 (0-29)0.824
Major complications, n (%)11 (9.2)200 (13.7)117 (14.0)28 (25.0)0.004
Table 2 Paired log-rank test in all pathological tumor-node-metastasis stages/pathological tumor-node-metastasis stage I/pathological tumor-node-metastasis stage II/pathological tumor-node-metastasis stage III

B
C
D
A0.054/0.497/0.030/0.0740.008/0.485/0.023/0.0060.031/0.952/0.136/0.070
B0.143/0.870/0.593/0.0810.246/0.426/0.750/0.428
C0.605/0.414/0.886/0.964
Table 3 Cox proportional hazard regression model for overall survival
Univariate
Multivariate1

HR (95%CI)
P value
HR (95%CI)
P value
Sex
MaleRefRef
Female0.897 (0.742-1.085)0.2630.970 (0.798-1.180)0.763
Age
< 65 yrRefRef
≥ 65 yr1.362 (1.162-1.598)< 0.0011.161 (0.985-1.367)0.075
Preoperative weight loss
0% or increasedRefRef
0%–5%1.210 (0.934-1.568)0.1480.964 (0.740-1.256)0.786
> 5%1.612 (1.355-1.918)< 0.0011.122 (0.937-1.342)0.210
BMI
18.5-24.9 kg/m2RefRef
25-29.9 kg/m20.883 (0.747-1.043)0.1430.885 (0.746-1.049)0.160
≥ 30 kg/m20.792 (0.533-1.177)0.2490.824 (0.551-1.230)0.343
< 18.5 kg/m21.368 (0.996-1.880)0.0531.558 (1.125-2.158)0.008
Tumor location
LowerRefRef
Middle1.049 (0.828-1.328)0.6921.098 (0.863-1.395)0.447
Upper1.886 (1.579-2.253)< 0.0011.409 (1.155-1.717)0.001
Entire3.512 (2.639-4.674)< 0.0011.748 (1.292-2.366)< 0.001
Tumor diameter
≤ 5 cmRefRef
> 5 cm2.488 (2.141-2.892)< 0.0011.256 (1.068-1.477)0.006
Borrmann type
EGCRefRef
I4.861 (3.082-7.666)< 0.0011.206 (0.659-2.208)0.544
II4.374 (2.971-6.440)< 0.0011.205 (0.685-2.120)0.518
III8.817 (6.114-12.717)< 0.0011.587 (0.905-2.784)0.107
IV14.778 (9.703-22.510)< 0.0011.967 (1.070-3.613)0.029
Histological type
DifferentiatedRefRef
Undifferentiated1.495 (1.237-1.806)< 0.0010.891 (0.724-10.96)0.275
PNI
NoRefRef
Yes2.785 (2.390-3.246)< 0.0011.064 (0.886-1.278)0.507
LVI
NoRefRef
Yes2.764 (2.355-3.243)< 0.0011.231 (1.039-1.457)0.016
pT status
1aRefRef
1b1.596 (0.778-3.274)0.2021.343 (0.652-2.765)0.424
23.338 (1.727-6.454)< 0.0011.607 (0.749-3.451)0.223
39.302 (5.086-17.012)< 0.0012.519 (1.201-5.284)0.014
4a17.766 (9.732-32.433)< 0.0013.898 (1.844-8.239)< 0.001
4b18.263 (9.415-35.427)< 0.0013.950 (1.778-8.775)< 0.001
pN status
0RefRef
13.055 (2.316-4.030)< 0.0011.787 (1.314-2.394)< 0.001
24.849 (3.717-6.326)< 0.0012.544 (1.898-3.411)< 0.001
3a9.325 (7.207-12.066)< 0.0014.095 (3.042-5.512)< 0.001
3b11.071 (8.540-14.352)< 0.0014.345 (3.182-5.932)< 0.001
eLNs
≥ 30RefRef
16–291.055 (0.901-1.236)0.5051.282 (1.083-1.518)0.004
< 160.944 (0.724-1.232)0.6721.515 (1.139-2.015)0.004