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©The Author(s) 2020.
World J Gastrointest Oncol. Oct 15, 2020; 12(10): 1119-1132
Published online Oct 15, 2020. doi: 10.4251/wjgo.v12.i10.1119
Published online Oct 15, 2020. doi: 10.4251/wjgo.v12.i10.1119
Table 1 Treatments for all patients, n (%)
| Surgical procedure | 2000-2004 (n = 853) | 2005-2009 (n = 1707) | 2010-2014 (n = 3327) | 2000-2014 (n = 5887) |
| Proximal gastrectomy | 60 (7) | 152 (8.9) | 228 (6.9) | 440 (7.5) |
| Subtotal distal gastrectomy | 398 (46.7) | 946 (55.4) | 1646 (49.5) | 2990 (50.8) |
| Total gastrectomy | 189 (22.2) | 354 (20.7) | 771 (23.2) | 1314 (22.3) |
| Palliative surgery | 80 (9.4) | 97 (5.7) | 193 (5.8) | 370 (6.3) |
| Exploratory laparotomy | 23 (2.7) | 45 (2.6) | 200 (6) | 268 (4.6) |
| No surgery | 103 (12.1) | 113 (6.6) | 289 (8.7) | 505 (8.6) |
Table 2 Clinicopathological characteristics of gastric cancer patients at different time periods, n (%)
| 2000-2004 (n = 647) | 2005-2009 (n = 1452) | 2010-2014 (n = 2645) | 2000-2014 (n = 4744) | P value | |
| Gender | 0.321 | ||||
| Male | 462 (71.4) | 1079 (74.3) | 1961 (74.1) | 3502 (73.8) | |
| Female | 185 (28.6) | 373 (25.7) | 684 (25.9) | 1242 (26.2) | |
| Age (yr) | 0.000 | ||||
| ≤ 45 | 110 (17) | 177 (12.2) | 286 (10.8) | 573 (12.1) | |
| 45-65 | 362 (56) | 822 (56.6) | 1695 (64.1) | 2879 (60.7) | |
| > 65 | 175 (27) | 453 (31.2) | 664 (25.1) | 1292 (27.2) | |
| Tumor location | 0.017 | ||||
| Upper third | 74 (11.4) | 158 (10.9) | 336 (12.7) | 568 (12) | |
| Middle third | 89 (13.8) | 237 (16.3) | 343 (13) | 669 (14.1) | |
| Lower third | 373 (57.7) | 836 (57.6) | 1586 (60) | 2795 (58.9) | |
| Whole stomach | 115 (17.8) | 221 (15.2) | 380 (14.3) | 712 (15) | |
| Tumor size (mm) | 0.000 | ||||
| < 50 | 192 (29.7) | 593 (40.8) | 1105 (41.8) | 1890 (39.8) | |
| ≥ 50 | 455 (70.3) | 859 (59.2) | 1540 (58.2) | 2854 (60.2) | |
| Histologic type | 0.000 | ||||
| Well/moderately differentiated | 184 (28.4) | 492 (33.9) | 1101 (41.6) | 1777 (37.5) | |
| Lowly/undifferentiated | 463 (71.6) | 960 (66.1) | 1544 (58.4) | 2967 (62.5) | |
| T stage | 0.000 | ||||
| T1 | 25 (3.9) | 121 (8.3) | 380 (14.4) | 526 (11.1) | |
| T2 | 112 (17.3) | 197 (13.6) | 258 (9.8) | 567 (12) | |
| T3 | 110 (17) | 155 (10.7) | 820 (31) | 1085 (22.9) | |
| T4 | 400 (61.8) | 979 (67.4) | 1187 (44.9) | 2566 (54.1) | |
| N stage | 0.000 | ||||
| N0 | 226 (34.9) | 493 (34) | 999 (37.8) | 1717 (36.2) | |
| N1 | 195 (30.1) | 285 (19.6) | 407 (15.4) | 888 (18.7) | |
| N2 | 126 (19.5) | 217 (14.9) | 422 (16) | 765 (16.1) | |
| N3 | 100 (15.5) | 457 (31.5) | 817 (30.9) | 1374 (29) | |
| M stage | 0.000 | ||||
| M0 | 572 (88.4) | 1352 (93.1) | 2484 (93.9) | 4408 (92.9) | |
| M1 | 75 (11.6) | 100 (6.9) | 161 (6.1) | 336 (7.1) | |
| TNM stage | 0.000 | ||||
| I | 65 (10) | 184 (12.7) | 468 (17.7) | 717 (15.1) | |
| II | 167 (25.8) | 360 (24.8) | 587 (22.2) | 1114 (23.5) | |
| III | 340 (52.6) | 808 (55.6) | 1429 (54) | 2577 (54.3) | |
| IV | 75 (11.6) | 100 (6.9) | 161 (6.1) | 336 (7.1) |
Table 3 Surgical characteristics of patients with gastric cancer at different time periods, n (%)
| 2000-2004 (n = 647) | 2005-2009 (n = 1452) | 2010-2014 (n = 2645) | 2000-2014 (n = 4744) | P value | |
| Type of gastrectomy | 0.010 | ||||
| Proximal gastrectomy | 60 (9.3) | 152 (10.5) | 228 (8.6) | 440 (9.3) | |
| Subtotal distal gastrectomy | 398 (61.5) | 946 (65.2) | 1646 (62.2) | 2990 (63) | |
| Total gastrectomy | 189 (29.2) | 354 (24.4) | 771 (29.1) | 1314 (27.7) | |
| Local infiltration | 0.014 | ||||
| Yes | 100 (15.5) | 268 (18.5) | 538 (20.3) | 906 (19.1) | |
| No | 547 (85.5) | 1184 (81.5) | 2107 (79.7) | 3838 (80.9) | |
| Margin status | 0.050 | ||||
| R0 | 536 (82.8) | 1139 (78.4) | 2133 (80.6) | 3808 (80.3) | |
| R1/R2 | 111 (17.2) | 313 (21.6) | 512 (19.4) | 936 (19.7) | |
| Joint resection | 0.000 | ||||
| Yes | 59 (9.1) | 36 (2.5) | 106 (4) | 201 (4.2) | |
| no | 588 (90.9) | 1416 (97.5) | 2539 (96) | 4543 (95.8) | |
| Early postoperative complications | 0.000 | ||||
| Yes | 24 (3.7) | 20 (1.4) | 141 (5.3) | 185 (3.9) | |
| No | 623 (96.3) | 1432 (98.6) | 2504 (94.7) | 4558 (96.1) | |
| No. of retrieved lymph nodes | 0.000 | ||||
| < 15 | 559 (86.4) | 633 (43.6) | 349 (13.2) | 1541 (32.5) | |
| 15-30 | 81 (12.5) | 678 (46.7) | 1294 (48.9) | 2053 (42.3) | |
| ≥ 30 | 7 (1.1) | 141 (9.7) | 1002 (37.9) | 1150 (24.2) |
Table 4 Univariate and multivariate analyses of prognostic factors in patients with gastric cancer
| Factor | Univariate analysis | Multivariate analysis | ||||
| HR | 95%CI | P value | HR | 95%CI | P value | |
| Gender | 1.026 | 0.944-1.114 | 0.547 | - | - | - |
| Age (yr) | 1.091 | 1.026-1.160 | 0.005 | 1.105 | 1.039-1.176 | 0.002 |
| Tumor location | 1.150 | 1.096-1.206 | 0.000 | 0.979 | 0.936-1.024 | 0.353 |
| Tumor size (mm) | 2.578 | 2.375-2.797 | 0.000 | 1.206 | 1.100-1.322 | 0.000 |
| Histologic type | 1.484 | 1.373-1.604 | 0.000 | 1.172 | 1.082-1.270 | 0.000 |
| TNM stage | 2.640 | 2.498-2.791 | 0.000 | 1.267 | 1.136-1.412 | 0.000 |
| T stage | 1.756 | 1.679-1.836 | 0.000 | 1.189 | 1.120-1.262 | 0.000 |
| N stage | 1.657 | 1.607-1.708 | 0.000 | 1.344 | 1.287-1.403 | 0.000 |
| M stage | 4.140 | 3.686-4.651 | 0.000 | 1.150 | 0.968-1.365 | 0.112 |
| Type of gastrectomy | 1.677 | 1.569-1.792 | 0.000 | 1.201 | 1.122-1.286 | 0.000 |
| Local infiltration | 0.320 | 0.295-0.347 | 0.000 | 0.662 | 0.602-0.727 | 0.000 |
| Margin status | 4.029 | 3.713-4.372 | 0.000 | 1.843 | 1.666-2.040 | 0.000 |
| Joint resection | 0.539 | 0.461-0.629 | 0.000 | 0.919 | 0.783-1.079 | 0.304 |
| Early postoperative complications | 0.975 | 0.808-1.177 | 0.794 | - | - | - |
| No. of retrieved lymph nodes | 0.872 | 0.830-0.916 | 0.000 | 0.847 | 0.796-0.901 | 0.000 |
| Year group | 0.774 | 0.737-0.813 | 0.000 | 0.859 | 0.808-0.913 | 0.000 |
- Citation: Zhai Z, Zhu ZY, Cong XL, Han BL, Gao JL, Yin X, Zhang Y, Lou SH, Fang TY, Wang YM, Li CF, Yu XF, Ma Y, Xue YW. Changing trends of clinicopathologic features and survival duration after surgery for gastric cancer in Northeast China. World J Gastrointest Oncol 2020; 12(10): 1119-1132
- URL: https://www.wjgnet.com/1948-5204/full/v12/i10/1119.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v12.i10.1119