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Copyright ©The Author(s) 2016.
World J Gastrointest Oncol. Apr 15, 2016; 8(4): 351-357
Published online Apr 15, 2016. doi: 10.4251/wjgo.v8.i4.351
Table 1 A comparison colitis-associated cancer and sporadic colorectal cancer
CAC: Up to 20% of UC patients develop CAC within 30 yr of disease onset
CAC: High overall mortality rate
NSAID use reduces the risk of CRC, suggesting a potential role for anticytokine therapy
CRC: Classic adenoma to carcinoma sequence
CAC: Chronic inflammation, injury, dysplasia, and CRC
The common genetic and signaling pathways are different between
CRC and CAC including β-catenin, p53, k-ras, B-raf
Both CRC and CAC are associated with transcription factors, such as
NF-κB and/or STAT3 which mediate the immune response and oncogenesis
Both CRC and CAC depend on the quality and quantity of intestinal microflora