Published online Apr 15, 2016. doi: 10.4251/wjgo.v8.i4.351
Peer-review started: May 5, 2015
First decision: July 1, 2015
Revised: January 24, 2016
Accepted: February 16, 2016
Article in press: February 17, 2016
Published online: April 15, 2016
Core tip: Inflammatory bowel disease, especially ulcerative colitis, is an important risk factor for development of colon cancer. There has been quite increased in the number of patients who had high-grade dysplasia and/or cancer. The relationship between inflammation and tumorigenesis is well-established and in the last decade has received a great deal of supporting evidence from genetic, pharmacological, and epidemiological data. To avoid such a problem, there is a need for appropriate diagnosis and treatment. It should be considered that actively introduce the surgical treatment in addition to medical treatment.