Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer

Figure 8 Genome-wide DNA methylation in colorectal cancer and adenoma of different grades. A: Differentially methylated regions (DMRs) between low-grade adenoma (LGA) and normal tissues, high-grade adenoma (HGA) and normal tissue, and HGA and LGA; B: DMRs between low-grade cancer (LGC) and normal tissues, high-grade cancer (HGC) and normal tissue, and HGC and LGC; C: Venn plot highlighting the relationships among all DMRs in ADE of different grades; D: Venn plot highlighting the relationships among all DMRs in CRC of different grades; E: The methylation-regulated differentially expressed gene (meDEG) methylation pattern in ADE of different grades; F: The meDEG methylation pattern in CRC of different grades; G: Expression level differences in AGTR1 and NECAB1 between different grades of ADE; H: Expression level differences in AGTR1 and NECAB1 between different grades of CRC. DMRs: Differentially methylated regions; LGA: Low-grade adenoma; HGA: High-grade adenoma; LGC: Low-grade cancer; HGC: High-grade cancer.