Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer

Figure 1 Adenoma and colorectal cancer methylation landscapes. A: Violin plots of global methylation levels of all CpG sites across the adenoma (ADE) and normal samples (A, adenoma; AN, adjacent normal); B: Principal component analysis (PCA) plots of WGBS data showing the distribution of ADE and normal samples according to CpG site methylation levels; C: Violin plots of global levels of methylation of all CpG sites across colorectal cancer (CRC) and normal samples (C, colorectal cancer; N, normal); D: PCA plots of WGBS data showing the distribution of CRC and normal samples according to CpG site methylation levels; E: Heatmap of the methylation values of the top 1000 differentially methylated positions (DMPs) between the ADE and normal group; F: Heatmap of the methylation values of the top 1000 DMPs between the ADE and normal group. ADE: Adenoma; CRC: Colorectal cancer.